Abstract
A nonlysogenic, non-toxinogenic strain was isolated from the PW8 strain of C. diphtheriae by two-step ultraviolet induction. This strain was lysed by phages derived from the PW8 strain but not by beta phages from the C7(beta) strain. When this cured strain was lysogenized with phages from the PW8 strain, toxin production by the resulting lysogens was about a half or a quarter of that of the parent strain PW8.
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- BARDSDALE W. L., PAPPENHEIMER A. M., Jr Phage-host relationships in nontoxigenic and toxigenic diphtheria bacilli. J Bacteriol. 1954 Feb;67(2):220–232. doi: 10.1128/jb.67.2.220-232.1954. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BARKSDALE L., GARMISE L., RIVERA R. Toxinogeny in Corynebacterium diphtheriae. J Bacteriol. 1961 Apr;81:527–540. doi: 10.1128/jb.81.4.527-540.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kanei C., Uchida T., Yoneda M. Isolation from corynebacterium diphtheriae C7(beta) of bacterial mutants that produce toxin in medium with excess iron. Infect Immun. 1977 Oct;18(1):203–209. doi: 10.1128/iai.18.1.203-209.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lampidis T., Barksdale L. Park-Williams number 8 strain of Corynebacterium diphtheriae. J Bacteriol. 1971 Jan;105(1):77–85. doi: 10.1128/jb.105.1.77-85.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mathews M. M., Miller P. A., Pappenheimer A. M., Jr Morphological observations on some diphtherial phages. Virology. 1966 Jul;29(3):402–409. doi: 10.1016/0042-6822(66)90216-9. [DOI] [PubMed] [Google Scholar]
- Matsuda M., Kanei C., Yoneda M. Degree of expression of the tox + gene introduced into corynebacteria by phages derived from diphtheria bacilli having different capacities to produce toxin. Biken J. 1971 Sep;14(3):365–368. [PubMed] [Google Scholar]
- Matsuda M., Kanei C., Yoneda M. Some properties of the phage of the Corynebacterium diphtheriae Park Williams No. 8 strain. Biken J. 1971 Jun;14(2):197–201. [PubMed] [Google Scholar]
- Maximescu P. New host-strains for the lysogenic Corynebacterium diphtheriae Park Williams No. 8 strain. J Gen Microbiol. 1968 Aug;53(1):125–133. doi: 10.1099/00221287-53-1-125. [DOI] [PubMed] [Google Scholar]
- Miller P. A., Pappenheimer A. M., Jr, Doolittle W. F. Phage-host relationships in certain strains of Corynebacterium diphtheriae. Virology. 1966 Jul;29(3):410–425. doi: 10.1016/0042-6822(66)90217-0. [DOI] [PubMed] [Google Scholar]
- Uchida T., Gill D. M., Pappenheimer A. M., Jr Mutation in the structural gene for diphtheria toxin carried by temperate phage . Nat New Biol. 1971 Sep 1;233(35):8–11. doi: 10.1038/newbio233008a0. [DOI] [PubMed] [Google Scholar]
- Uchida T., Pappenheimer A. M., Jr, Greany R. Diphtheria toxin and related proteins. I. Isolation and properties of mutant proteins serologically related to diphtheria toxin. J Biol Chem. 1973 Jun 10;248(11):3838–3844. [PubMed] [Google Scholar]
- Weber K., Osborn M. The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. J Biol Chem. 1969 Aug 25;244(16):4406–4412. [PubMed] [Google Scholar]
- YONEDA M. A new culture method designed for kinetic studies on diphtheria toxin production. Br J Exp Pathol. 1957 Apr;38(2):190–193. [PMC free article] [PubMed] [Google Scholar]

