Abstract
An experimental model of pneumonic pasteurellosis in sheep was used to investigate the role of serum antibody in resistance to this disease. Lambs which had been vaccinated with a sodium salicylate extract of Pasteurella haemolytica type A1 were protected against challenge with PI3 virus followed by P. haemolytica type A1 7 days later. The majority of untreated lambs and lambs which had received either 200 ml of antiserum to P. haemolytica or 200 ml of control serum intraperitoneally 18 h before infection with P. haemolytica type A1 succumbed to the challenge. Lymphocytes from vaccinated lambs showed a specific proliferative response when exposed to P. haemolytica type A1 sodium salicylate extract, and this response increased after exposure of these animals to P. haemolytica type A1 in aerosol. The results indicate that the humoral immune response alone is incapable of affording protection against experimental pasteurellosis and that cell-mediated immunity may play an important part in resistance to this disease.
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- Burrells C., Wells P. W., Sutherland A. D. Reactivity of ovine lymphocytes to phytohaemagglutinin and pokeweed mitogen during pregnancy and in the immediate post-parturient period. Clin Exp Immunol. 1978 Sep;33(3):410–415. [PMC free article] [PubMed] [Google Scholar]
- Gilmour N. J., Martin W. B., Sharp J. M., Thompson D. A., Wells P. W. The development of vaccines against pneumonic pasteurellosis in sheep. Vet Rec. 1979 Jan 6;104(1):15–15. doi: 10.1136/vr.104.1.15. [DOI] [PubMed] [Google Scholar]
- Gregerson D. S., Kelly B., Levy J. G. Responses of guinea-pig lymphocytes to mitogens, an antigen, and mixed leucocyte culture in media with and without mercaptoethanol and foetal calf serum. Immunology. 1975 Aug;29(2):237–246. [PMC free article] [PubMed] [Google Scholar]
- Sharp J. M., Gilmour N. J., Thompson D. A., Rushton B. Experimental infection of specific pathogen-free lambs with parainfluenza virus type 3 and Pasteurella haemolytica. J Comp Pathol. 1978 Apr;88(2):237–243. doi: 10.1016/0021-9975(78)90027-0. [DOI] [PubMed] [Google Scholar]
- Shreeve B. J., Biberstein E. L., Thompson D. A. Variation in carrier rates of Pasteurella haemolytica in sheep. II. Diseased flocks. J Comp Pathol. 1972 Jan;82(1):111–116. doi: 10.1016/0021-9975(72)90034-5. [DOI] [PubMed] [Google Scholar]
- Smith W. D., Wells P. W., Burrells C., Dawson A. M. Maternal immunoglobulins and parainfluenza 3 virus inhibitors in the nasal and lachrymal secretions and serum of newborn lambs. Clin Exp Immunol. 1976 Mar;23(3):544–553. [PMC free article] [PubMed] [Google Scholar]
- Wells P. W., Dawson A. M., Smith W. D., Smith B. S. The transfer of circulating 131I IgG1 and 125I IgG2 to the nasal secretions of sheep. Res Vet Sci. 1977 Mar;22(2):201–204. [PubMed] [Google Scholar]
- Wells P. W., Sharp J. M., Burrells C., Rushton B., Smith W. D. The assessment in sheep of an inactivated vaccine of parainfluenza 3 virus incorporating double stranded RNA (BRL 5907) as adjuvant. J Hyg (Lond) 1976 Oct;77(2):255–261. doi: 10.1017/s0022172400024682. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wells P. W., Sharp J. M., Rushton B., Gilmour N. J., Thompson D. A. The effect of vaccination with a parainfluenza type 3 virus on pneumonia resulting from infection with parainfluenza type 3 virus and Pasteurella haemolytica. J Comp Pathol. 1978 Apr;88(2):253–259. doi: 10.1016/0021-9975(78)90029-4. [DOI] [PubMed] [Google Scholar]
- Woolcock J. B., Collins F. M. Immune mechanism in Pasteurella multocida-infected mice. Infect Immun. 1976 Mar;13(3):949–958. doi: 10.1128/iai.13.3.949-958.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]