Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1979 Oct;26(1):30–35. doi: 10.1128/iai.26.1.30-35.1979

Reduction of contact sensitivity reactions to oxazolone in mite-infested mice.

H Laltoo, L S Kind
PMCID: PMC414570  PMID: 500208

Abstract

Oxazolone-sensitized mite-infested (SWR-M) and mite-free (SWR-J) mice were challenged with oxazolone on the skin of the neck and shoulder. The migration of radioactively labeled cells to the site of contact sensitivity reaction to oxazolone was significantly less in SWR-M than in SWR-J mice. Serum obtained from SWR-M mice suppressed the extravasation of cells into the skin site of SWR-J mice challenged with oxazolone. The decrease in cellular influx in SWR-M mice occurred in areas of mite infestation (skin of neck and shoulder) as well as in areas not infested with mites (the ears). SWR-M mice also gave evidence of enhanced vascular permeability. A possible role for histamine in the inhibition of contact sensitivity in mite-infested mice is discussed.

Full text

PDF
30

Images in this article

31Image
on p.31
32Image
on p.32

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asherson G. L., Ptak W. Contact and delayed hypersensitivity in the mouse. I. Active sensitization and passive transfer. Immunology. 1968 Sep;15(3):405–416. [PMC free article] [PubMed] [Google Scholar]
  2. Barriga O. O. Depression of cell-mediated immunity following inoculation of Trichinella spiralis extract in the mouse. Immunology. 1978 Jan;34(1):167–173. [PMC free article] [PubMed] [Google Scholar]
  3. Blackwood L. L., Molinari J. A. Effect of Trichinella spiralis infection on delayed hypersensitivity to heterologous antigens. Int Arch Allergy Appl Immunol. 1978;57(1):8–14. doi: 10.1159/000232077. [DOI] [PubMed] [Google Scholar]
  4. Coulis P. A., Lewert R. M., Fitch F. W. [Splenic suppressor cells and cell-mediated cytotoxicity in murine schistosomiasis]. J Immunol. 1978 Jan;120(1):58–60. [PubMed] [Google Scholar]
  5. Gershon R. K., Askenase P. W., Gershon M. D. Requirement for vasoactive amines for production of delayed-type hypersensitvity skin reactions. J Exp Med. 1975 Sep 1;142(3):732–747. doi: 10.1084/jem.142.3.732. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kedar E., Bonavida B. Histamine receptor-bearing leukocytes (HRL). I. Detection of histamine receptor-bearing cells by rosette formation with histamine-coated erythrocytes. J Immunol. 1974 Nov;113(5):1544–1552. [PubMed] [Google Scholar]
  7. Laltoo H., Van Zoost T., Kind L. S. IgE antibody response to mite antigens in mite infested mice. Immunol Commun. 1979;8(1):1–9. doi: 10.3109/08820137909044702. [DOI] [PubMed] [Google Scholar]
  8. Lobitz W. C., Jr, Honeyman J. F., Winkler N. W. Suppressed cell-mediated immunity in two adults with atopic dermatitis. Br J Dermatol. 1972 Apr;86(4):317–328. doi: 10.1111/j.1365-2133.1972.tb05045.x. [DOI] [PubMed] [Google Scholar]
  9. McGeady S. J., Buckley R. H. Depression of cell-mediated immunity in atopic eczema. J Allergy Clin Immunol. 1975 Nov;56(5):393–406. doi: 10.1016/0091-6749(75)90133-5. [DOI] [PubMed] [Google Scholar]
  10. Melmon K. L., Bourne H. R., Weinstein J., Sela M. Receptors for histamine can be detected on the surface of selected leukocytes. Science. 1972 Aug 25;177(4050):707–709. doi: 10.1126/science.177.4050.707. [DOI] [PubMed] [Google Scholar]
  11. Miller J. F., Vadas M. A., Whitelaw A., Gamble J. A radioisotopic method to measure delayed type hypersensitivity in the mouse. II. Cell transfer studies. Int Arch Allergy Appl Immunol. 1975;49(5):693–708. doi: 10.1159/000231450. [DOI] [PubMed] [Google Scholar]
  12. Otsuki J. A., Grassick R., Seymour D., Kind L. S. The use of 3H serotonin release from mast cells of the mouse as an assay for mediator liberation. Immunol Commun. 1976;5(1-2):27–39. doi: 10.3109/08820137609020610. [DOI] [PubMed] [Google Scholar]
  13. Ottesen E. A., Smith T. K., Kirkpatrick C. H. Immune response to Trichinella spiralis in the rat. I. Development of cellular and humoral responses during chronic infection. Int Arch Allergy Appl Immunol. 1975;49(3):396–410. [PubMed] [Google Scholar]
  14. Pelley R. P., Ruffier J. J., Warren K. S. Suppressive effect of a chronic helminth infection, schistosomiasis mansoni, on the in vitro responses of spleen and lymph node cells to the T cell mitogens phytohemagglutinin and concanavalin A. Infect Immun. 1976 Apr;13(4):1176–1183. doi: 10.1128/iai.13.4.1176-1183.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Pelley R. P., Warren K. S. Immunoregulation in chronic infectious disease: schistosomiasis as a model. J Invest Dermatol. 1978 Jul;71(1):49–55. doi: 10.1111/1523-1747.ep12543940. [DOI] [PubMed] [Google Scholar]
  16. Rocklin R. E., Greineder D., Littman B. H., Melmon K. L. Modulation of cellular immune function in vitro by histamine receptor-bearing lymphocytes: mechanism of action. Cell Immunol. 1978 Apr;37(1):162–173. doi: 10.1016/0008-8749(78)90184-3. [DOI] [PubMed] [Google Scholar]
  17. Rocklin R. E. Modulation of cellular-immune responses in vivo and in vitro by histamine receptor-bearing lymphocytes. J Clin Invest. 1976 Apr;57(4):1051–1058. doi: 10.1172/JCI108347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Sabbadini E., Neri A., Sehon A. H. Localization of non-immune radioactively labelled cells in the lesions of contact sensitivity in mice. J Immunol Methods. 1974 May;5(1):9–19. doi: 10.1016/0022-1759(74)90041-6. [DOI] [PubMed] [Google Scholar]
  19. Saelinger C. B., Higginbotham R. D. Hypersensitivity responses to bee venom and the mellitin. Int Arch Allergy Appl Immunol. 1974;46(1):28–37. doi: 10.1159/000231110. [DOI] [PubMed] [Google Scholar]
  20. Svet-Moldavsky G. J., Shaghijan G. S., Chernyakhovskaya I. Y., Mkheidze D. M., Litovchenko T. A., Ozeretskovskaya N. N., Kadaghidze Z. G. Inhibition of skin allograft rejection in trichinella-infected mice. Transplantation. 1970 Jan;9(1):69–71. doi: 10.1097/00007890-197001000-00020. [DOI] [PubMed] [Google Scholar]
  21. Vadas M. A., Miller J. F., Gamble J., Whitelaw A. A radioisotopic method to measure delayed type hypersensitivity in the mouse. I. Studies in sensitized and normal mice. Int Arch Allergy Appl Immunol. 1975;49(5):670–692. doi: 10.1159/000231449. [DOI] [PubMed] [Google Scholar]
  22. WHITELEY H. J., HORTON D. L. The effect of Myobia musculi on the epidermis and hair regrowth cycle in the ageing CBA mouse. J Pathol Bacteriol. 1962 Apr;83:509–514. doi: 10.1002/path.1700830224. [DOI] [PubMed] [Google Scholar]
  23. Wang S. R., Zweiman B. Histamine suppression of human lymphocyte responses to mitogens. Cell Immunol. 1978 Mar 1;36(1):28–36. doi: 10.1016/0008-8749(78)90247-2. [DOI] [PubMed] [Google Scholar]
  24. Warren K. S., Grove D. I., Pelley R. P. The Schistosoma japonicum egg granuloma. II. Cellular composition, granuloma size, and immunologic concomitants. Am J Trop Med Hyg. 1978 Mar;27(2 Pt 1):271–275. doi: 10.4269/ajtmh.1978.27.271. [DOI] [PubMed] [Google Scholar]
  25. Weisbroth S. H., Friedman S., Scher S. The parasitic ecology of the rodent mite, Myobia musculi. III. Lesions in certain host strains. Lab Anim Sci. 1976 Oct;26(5):725–735. [PubMed] [Google Scholar]
  26. Weisbroth S. H., Powell M. B., Roth L., Scher S. Immunopathology of naturally occurring otodectic otoacariasis in the domestic cat. J Am Vet Med Assoc. 1974 Dec 15;165(12):1088–1093. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES