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. 1979 Nov;26(2):408–414. doi: 10.1128/iai.26.2.408-414.1979

Prostaglandin regulation of colony-stimulating factor production by lipopolysaccharide-stimulated murine leukocytes.

R N Moore, R Urbaschek, L M Wahl, S E Mergenhagen
PMCID: PMC414629  PMID: 397926

Abstract

The production of colony-stimulating factor by lipopolysaccharide-stimulated murine peritoneal leukocytes and their adherent subpopulations (greater than 80% macrophages) was markedly enhanced by indomethacin at concentrations sufficient to block prostaglandin E synthesis. Addition of physiological concentrations of E-series prostaglandins reversed this enhancing effect of indomethacin in a dose-dependent manner. These results indicate that colony-stimulating factor production by stimulated leukocytes is regulated by E-series prostaglandins and suggest that prostaglandins function to limit myelopoiesis by inhibiting colony-stimulating factor production and concomitantly the induction of cell proliferation.

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Selected References

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