Figure 8.

Spatial reference memory. Sevoflurane did not affect spatial reference memory. Environmental enrichment improved performance in sevoflurane-treated rats.

Escape latency to the hidden platform (A). At the second session, escape latency of sevoflurane-treated animals housed in an enriched environment is lower than latency of sevoflurane-treated rats housed conventionally. Swim speeds (B) and sessions to reach the platform in 30 seconds, averaged over three trials (C). Probe trial (platform removed) target quadrant dwell times on days 0 and 3 after completion of spatial reference memory testing (D–E). The dotted line indicates chance performance. *P<0.05, Kruskall Wallis test with Dunn’s Multiple Comparisons Test (data from one or more groups did not pass normality test). a P<0.001, b P<0.01, c P<0.05, Bonferroni post hoc comparisons.

CCW counterclockwise, CW clockwise EE enriched environment, NH normal housing, Sevo sevoflurane