Abstract
The susceptibility of a few strains of mice to a subcutaneous injection of Leishmania tropica major, the causative agent of cutaneous leishmaniasis in humans, was studied. The infection in six strains (CBA, AKR/J, AKR/cu, C57BL/6, A/J, and C3H) remained cutaneous, and the animals recovered within 3 to 4 months. In contast, the infection in BALB/c became generalized and killed 1005 of infected animals. Intraperitoneal injection of infected liver of BALB/c to A/J and syngeneic mice produced a lethal disease in BALB/c but no infection in A/J mice. Lower doses of the parasite produced a lethal infection in BALB/c but no apparent disease in A/J. Hence, the host rather than the parasite is responsible for the outcome of the disease. The peak antibody titer of BALB/c mice was not significantly higher than that of A/J mice. However, BALB/c failed to show any delayed hypersensitivity to leishmania tested by footpad reaction, whereas A/J mice showed a strong response.
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Selected References
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- Behin R., Mauel J., Rowe D. S. Mechanisms of protective immunity in experimental cutaneous leishmaniasis of the guinea-pig. III. Inhibition of leishmanial lesion in the guinea-pig by delayed hypersensitivity reaction to unrelated antigens. Clin Exp Immunol. 1977 Aug;29(2):320–325. [PMC free article] [PubMed] [Google Scholar]
- Blewett T. M., Kadivar D. M., Soulsby E. J. Cutaneous leishmaniasis in the guinea pig. Delayed-type hypersensitivity, lymphocyte stimulation, and inhibition of macrophage migration. Am J Trop Med Hyg. 1971 Jul;20(4):546–551. [PubMed] [Google Scholar]
- Bradley D. J. Letter: Genetic control of natural resistance to Leishmania donovani. Nature. 1974 Jul 26;250(464):353–354. doi: 10.1038/250353a0. [DOI] [PubMed] [Google Scholar]
- Bradley D. J. Regulation of Leishmania populations within the host. II. genetic control of acute susceptibility of mice to Leishmania donovani infection. Clin Exp Immunol. 1977 Oct;30(1):130–140. [PMC free article] [PubMed] [Google Scholar]
- Bryceson A. D., Bray R. S., Wolstencroft R. A., Dumonde D. C. Immunity in cutaneous leishmaniasis of the guinea-pig. Clin Exp Immunol. 1970 Sep;7(3):301–341. [PMC free article] [PubMed] [Google Scholar]
- Garnham P. C., Humphrey J. H. Problems in leishmaniasis related to immunology. Curr Top Microbiol Immunol. 1969;48:29–42. doi: 10.1007/978-3-642-46163-7_2. [DOI] [PubMed] [Google Scholar]
- Javadian E., Nadim A., Tahvildare-Bidruni G., Assefi V. Epidemiology of cutaneous leishmaniasis in Iran: B. Khorassan Part V: Report on a focus of zoonotic cutaneous leishmaniasis in Esferayen. Bull Soc Pathol Exot Filiales. 1976 Mar-Apr;69(2):140–143. [PubMed] [Google Scholar]
- Mackaness G. B. The influence of immunologically committed lymphoid cells on macrophage activity in vivo. J Exp Med. 1969 May 1;129(5):973–992. doi: 10.1084/jem.129.5.973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Preston P. M., Carter R. L., Leuchars E., Davies A. J., Dumonde D. C. Experimental cutaneous leishmaniasis. 3. Effects of thymectomy on the course of infection of CBA mice with Leishmania tropica. Clin Exp Immunol. 1972 Feb;10(2):337–357. [PMC free article] [PubMed] [Google Scholar]
- Turk J. L., Bryceson A. D. Immunological phenomena in leprosy and related diseases. Adv Immunol. 1971;13:209–266. doi: 10.1016/s0065-2776(08)60185-6. [DOI] [PubMed] [Google Scholar]
- Weintraub J., Weinbaum F. I. The effect of BCG on experimental cutaneous leishmaniasis in mice. J Immunol. 1977 Jun;118(6):2288–2290. [PubMed] [Google Scholar]