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. 1979 Dec;26(3):996–999. doi: 10.1128/iai.26.3.996-999.1979

Cytotaxin receptors of neutrophils: evidence that F-methionyl peptides and pepstatin share a common receptor.

R D Nelson, S K Ackerman, V D Fiegel, M P Bauman, S D Douglas
PMCID: PMC414717  PMID: 528062

Abstract

Pepstatin, a chemotactic microbial pentapeptide, competes with f-Met-Leu-[3H]Phe for binding to human neutrophils. Furthermore, porcine neutrophils, which neither specifically bind nor respond chemotactically to the synthetic f-methionyl peptides, also fail to respond chemotactically to pepstatin. These results suggest that pepstatin shares a receptor on the neutrophil with f-methionyl peptides, despite their completely different amino acid compositions. The specificity of this cytotaxin receptor may therefore be broader than expected and depend on ligand characteristics distinct from primary structure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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