Table 1. Prognostic factors for progression free survival based on univariate analyses and final multivariate model.

	Univariate Analysis					Multivariate Analysis
Factors	Total No.	No. of Events	5-Year PFS (%)	Cumulative Hazard Ratio	Log-Rank P		P	Hazard Ratio (95% CI)
Age
≤ 65	71	40	44.3	1				1
> 65	28	19	18.1	2.052	0.01		0.508	1.252 (0.643-2.437)
Sex
Male	64	38	36.4	1
Female	35	21	41.4	1.054
ECOG
0,1	83	48	41.7	1				1
2,3	16	11	14.6	2.66	0.004		0.309	1.523 (0.677-3.425)
Genetic status
Exon9	17	12	38.6	1
Exon11	64	39	36.2	0.786
Wild type	11	6	36.4	0.902	0.751
Sum of tumor, cm
< 11.5	54	28	46.7	1				1
≥ 11.5	45	32	21.5	1.859	0.02		0.047	2.28 (1.19-3.29)
Hemoglobin (g/dL)
< 12	54	28	27.0	1
≥ 12	45	32	39.7	0.807	0.429
HCT (%)
< 36	55	35	27.2	1
≥ 36	44	26	36.9	0.887	0.662
MCV (fL)
< 80	22	13	27.9	1
≥ 80	77	49	33.8	1.096	0.787
Platelet (/μL)
< 150000	10	9	0	1
≥ 150000	89	51	37.1	3.371	0.001		0.052	0.352 (0.125-1.02)
Albumin (g/dL)
< 3.5	34	22	33.5	1
≥ 3.5	65	37	35.8	0.797	0.469
INR
≤ 1.2	78	45	36.2	1
> 1.2	21	15	31.2	1.268	0.56
BUN (mg/dL)
≤ 21	86	52	34.2	1
> 21	13	9	25.0	1.283	0.542
Creatinine (mg/dL)
≤ 1.03	62	38	33.9	1
> 1.03	37	22	34.7	0.835	0.517
AST (U/L)
< 34	80	44	40.5	1				1
≥ 34	19	17	8.3	2.58	0.002		0.032	2.087 (1.067-4.082)
ALT (U/L)
< 36	83	43	33.7	1
≥ 36	16	10	23.8	1.511	0.239
ALK-P (U/L)
< 94	77	44	36.3	1
≥ 94	22	17	18.3	1.616	0.138
Bil (T)
< 1.0	78	49	31.9	1
≥ 1.0	21	10	36.6	0.728	0.415
Sodium (mEq/L)
< 139	42	27	24.0	1
≥ 139	57	36	39.0	0.803	0.803
Potassium (mEq/L)
≤ 4	38	25	28.0	1
> 4	61	37	37.4	0.825	0.53
AURKA
< 60	52	22	60.5	1				1
> 60	47	37	7.4	10.74	< 0.001		< 0.001	6.567 (2.875-14.999)
Response
CR/PR	64	31	50.9	1			< 0.001	1
SD	24	17	20.2	2.204			0.045	1.75 (1.016-4.27)
PD	11	11	0.0	NA	< 0.001		< 0.001	180.72 (20.19-1617.31)