Table 2. Prognostic factors for overall survival based on univariate analyses and final multivariate model.

	Univariate Analysis					Multivariate Analysis
Factors	Total No.	No. of Events	5-Year OS (%)	Cumulative Hazard Ratio	Log-Rank P		P	Hazard Ratio (95% CI)
Age
< 65	71	22	68.1	1				1
> 65	28	19	36.8	3.28	< 0.001		0.118	2.718 (0.775-9.526)
Sex
Male	64	26	60.4	1
Female	35	15	57.4	1.126	0.726
ECOG
0,1	83	30	67	1				1
2,3	16	11	0	4667	< 0.001		0.082	3.082 (0.866-10.978)
Genetic status
Exon9	17	7	60.8	1
Exon11	64	28	59.4	1.24
Wild type	11	5	51.1	1.349	0.848
Sum of tumor, cm
< 11.5	54	18	68.7	1				1
≥ 11.5	45	23	49.2	1.941	0.037		0.039	3.228 (1.14-12.177)
Hemoglobin (g/dL)
< 12	54	23	52.8	1
≥ 12	45	19	63	0.752	0.378
HCT (%)
< 36	48	23	49.9	1
≥ 36	51	21	63.2	0.684	0.242
MCV (fL)
< 80	22	10	56.2	1
≥ 80	77	33	57.8	0.90	0.782
Platelet (/μL)
< 150000	10	6	32.4	1				1
≥ 150000	89	35	60.3	2.98	0.011		0.695	1.386 (0.271-7.096)
Albumin (g/dL)
< 3.5	34	19	44.2	1				1
≥ 3.5	65	21	68.1	0.494	0.05		0.094	0.408 (0.143-1.165)
INR
≤ 1.2	78	27	62.2	1
> 1.2	21	13	45.5	1.899	0.158
BUN (mg/dL)
≤ 21	86	34	60.8	1
> 21	13	9	35	1.985	0.109
Creatinine (mg/dL)
≤ 1.03	62	27	55.9	1
> 1.03	37	15	61.3	0.954	0.887
AST (U/L)
< 34	80	28	65.6	1				1
≥ 34	19	14	31.3	2.58	0.006		0.9	1.073 (0.360-3.196)
ALT (U/L)
< 36	83	35	59.7	1
≥ 36	16	8	45.8	1.212	0.648
ALK-P (U/L)
< 94	77	30	59.7	1
≥ 94	22	12	57	1.413	0.374
Bil (T)
< 1.0	78	31	61.1	1
≥ 1.0	21	10	44.5	1.286	0.54
Sodium (mEq/L)
< 139	42	25	44.1	1				1
≥ 139	57	18	67.2	0.437	0.02		0.058	0.348 (0.117-1.036)
Potassium (mEq/L)
≤ 4	38	18	49.3	1
> 4	61	25	62.3	0.827	0.601
AURKA
< 60	52	11	83	1				1
> 60	47	30	31.1	6.748	< 0.001		0.002	9.319(2.320-37.428)
Response
CR/PR	64	23	63.8	1				1
SD	24	8	71	1.015			0.237	0.394(0.084-1.846)
PD	11	10	13.6	5.95	< 0.0001		0.145	2.748(0.707-10.685)