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. 1979 Dec;26(3):1088–1092. doi: 10.1128/iai.26.3.1088-1092.1979

Production of hydroxyl radical by human alveolar macrophages.

J R Hoidal, G D Beall, J E Repine
PMCID: PMC414731  PMID: 528049

Abstract

Stimulated human alveolar macrophages were demonstrated to oxidize B-methyl proprionaldehyde (methional) or 2-keto-4-thiomethylbutyric acid to ethylene (C2H4). Agents which are believed to scavenge the hydroxyl radical (.OH), sodium benzoate, and mannitol, as well as scavengers of superoxide anion (O2-) or hydrogen peroxide, decreased C2H4 production, implicaing .OH as the oxidizing radical. Differences in C2H4 rpoduction, as well as oxygen uptake and O2- release between human alveolar macrophages and polymorphonuclear leukocytes, were also documented.

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Selected References

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