Abstract
Inbred mouse strains differ in susceptibility to intracorneal challenge with Pseudomonas aeruginosa. Genetic studies indicate that resistance to corneal infection is dominant over susceptibility and is controlled by autosomal genes, at least one of which is located outside of the H-2 locus. On the basis of genetic complementation studies, the susceptible strains BALB/c and C57BL/6 each bear one resistance gene, since the F1 hybrid (BALB/c X C57BL/6) was uniformly resistant to infection.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Benacerraf B., McDevitt H. O. Histocompatibility-linked immune response genes. Science. 1972 Jan 21;175(4019):273–279. doi: 10.1126/science.175.4019.273. [DOI] [PubMed] [Google Scholar]
- Bradley D. J., Kirkley J. Variation in susceptibility of mouse strains to Leishmania donovani infection. Trans R Soc Trop Med Hyg. 1972;66(4):527–528. [PubMed] [Google Scholar]
- Bradley D. J. Letter: Genetic control of natural resistance to Leishmania donovani. Nature. 1974 Jul 26;250(464):353–354. doi: 10.1038/250353a0. [DOI] [PubMed] [Google Scholar]
- Cheers C., McKenzie I. F. Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis. Infect Immun. 1978 Mar;19(3):755–762. doi: 10.1128/iai.19.3.755-762.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Groves M. G., Osterman J. V. Host defenses in experimental scrub typhus: genetics of natural resistance to infection. Infect Immun. 1978 Feb;19(2):583–588. doi: 10.1128/iai.19.2.583-588.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hazlett L. D., Berk R. S. Heightened resistance of athymic, nude (nu/nu) mice to experimental Pseudomonas aeruginosa ocular infection. Infect Immun. 1978 Dec;22(3):926–933. doi: 10.1128/iai.22.3.926-933.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pennington J. E., Williams R. M. Influence of genetic factors on natural resistance of mice to Pseudomonas aeruginosa. J Infect Dis. 1979 Apr;139(4):396–400. doi: 10.1093/infdis/139.4.396. [DOI] [PubMed] [Google Scholar]
- Plant J., Glynn A. A. Genetics of resistance to infection with Salmonella typhimurium in mice. J Infect Dis. 1976 Jan;133(1):72–78. doi: 10.1093/infdis/133.1.72. [DOI] [PubMed] [Google Scholar]
- Plant J., Glynn A. A. Natural resistance to Salmonella infection, delayed hypersensitivity and Ir genes in different strains of mice. Nature. 1974 Mar 22;248(446):345–347. doi: 10.1038/248345a0. [DOI] [PubMed] [Google Scholar]