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. 1974 Feb;9(2):199–205. doi: 10.1128/iai.9.2.199-205.1974

Pathogenesis of Rinderpest Virus Infection in Rabbits I. Clinical Signs, Immune Response, Histological Changes, and Virus Growth Patterns

Kazuya Yamanouchi 1, Fumitoshi Chino 1, Fumio Kobune 1, Akiko Fukuda 1, Yasuhiro Yoshikawa 1
PMCID: PMC414787  PMID: 4593339

Abstract

Rabbits were intravenously inoculated with an attenuated rinderpest virus (L strain), and general patterns of the disease were investigated. The rabbits developed fever with concomitant occurrence of diarrhea and lymphopenia. Early production of interferon was followed by a rise of neutralizing antibody. Histological examinations revealed an involvement of all of the lymphoid tissues, with primary lesions consisting of necrosis of the lymphoid follicles and formation of giant cells. Immunofluorescent examinations suggested that the virus growth was present in almost all of the lymphoid tissues. The possibility of application of this experimental system for the study of systemic infection by measles virus was discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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