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. 1974 Feb;9(2):323–328. doi: 10.1128/iai.9.2.323-328.1974

Neuraminidase Activity in Streptococcus sanguis and in the Viridans Group, and Occurrence of Acylneuraminate Lyase in Viridans Organisms Isolated from Patients with Septicemia

H E Müller 1
PMCID: PMC414804  PMID: 4816461

Abstract

The enzyme neuraminidase (EC 3.2.1.18) was found to be strongly active in different types of Streptococcus sanguis and S. viridans, and, in addition, the occurrence of the enzyme acylneuraminate pyruvate lyase (EC 4.1.3.3) was described in S. viridans. The enzyme-active bacteria strains were isolated from blood cultures of patients with septicemia. Whereas S. sanguis lost its strong neuraminidase activity after some weeks, S. viridans retained its enzyme activity for a long time in culture. Immunoelectrophoretic studies of the blood cultures of patients with streptococcal infections showed the loss of neuraminic acid in most glycoproteins of the serum, proving the in vivo action of neuraminidase. The pathogenic role of neuraminidase is discussed in streptococcal septicemia from the viewpoint of present knowledge.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Colman G. The application of computers to the classification of streptococci. J Gen Microbiol. 1968 Jan;50(1):149–158. doi: 10.1099/00221287-50-1-149. [DOI] [PubMed] [Google Scholar]
  2. Fischer K., Poschmann A., Oster H. Hämolyse bei schwerer Pneumonie infolge Neuraminidasewirkung Immunfluorescenzdarstellung der Cryptantigene. Monatsschr Kinderheilkd. 1971 Jan;119(1):2–8. [PubMed] [Google Scholar]
  3. Hayano S., Tanaka A., Okuyama Y. Distribution and serological specificity of sialidase produced by various groups of streptococci. J Bacteriol. 1969 Oct;100(1):354–357. doi: 10.1128/jb.100.1.354-357.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hayano S., Tanaka A. Sialidase-like enzymes produced by group A, B, C, G, and L streptococci and by Streptococcus sanguis. J Bacteriol. 1969 Mar;97(3):1328–1333. doi: 10.1128/jb.97.3.1328-1333.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hayano S., Tanaka A. Streptococcal sialidase. I. Isolation and properties of sialidase produced by group K Streptococcus. J Bacteriol. 1967 Jun;93(6):1753–1757. doi: 10.1128/jb.93.6.1753-1757.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hayano S., Tanaka A. Streptococcal sialidase. II. Kinetic and immunological studies of sialidase produced by group K streptococcus. J Bacteriol. 1968 May;95(5):1551–1554. doi: 10.1128/jb.95.5.1551-1554.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kelly R. T., Farmer S., Greiff D. Neuraminidase activities of clinical isolates of Diplococcus pneumoniae. J Bacteriol. 1967 Jul;94(1):272–273. doi: 10.1128/jb.94.1.272-273.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kelly R., Greiff D. Toxicity of pneumococcal neuraminidase. Infect Immun. 1970 Jul;2(1):115–117. doi: 10.1128/iai.2.1.115-117.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Müller H. E. Die Neuraminidase als pathogenetischer Faktor bei Gasödem-Infektionen durch Clostridium perfringens. Dtsch Med Wochenschr. 1970 Mar 6;95(10):513–517. doi: 10.1055/s-0028-1108495. [DOI] [PubMed] [Google Scholar]
  10. Müller H. E. Methodische Untersuchungen in vitro zur Einwirkung bakterieller Proteasen auf menschliche Plasmaeiweisskörper, dargestellt am Beispiel von Pseudomonas aeruginosa. Zentralbl Bakteriol Orig. 1971;216(1):79–87. [PubMed] [Google Scholar]
  11. Müller H. E. Uber das Vorkommen von Neuraminidase bei Corynebacterium acnes. Z Med Mikrobiol Immunol. 1971;156(3):240–249. [PubMed] [Google Scholar]
  12. Müller H. E. Uber das Vorkommen von Neuraminidase und Acylneuraminat-Pyruvat-Lyase bei Fusobacterium polymorphum und ihre patho-genetische Bedeutung. Zentralbl Bakteriol Orig A. 1973 Jul;224(2):212–219. [PubMed] [Google Scholar]
  13. Müller H. E., Werner H. Die Neuraminidase als pathogenetischer Faktor bei einem durch Bacteroides fragilis bedingten Abscess. Z Med Mikrobiol Immunol. 1970;156(1):98–106. [PubMed] [Google Scholar]
  14. Pinter J. K., Hayashi J. A., Bahn A. N. Carbohydrate hydrolases of oral streptococci. Arch Oral Biol. 1969 Jul;14(7):735–744. doi: 10.1016/0003-9969(69)90165-4. [DOI] [PubMed] [Google Scholar]
  15. Pinter J. K., Hayashi J. A., Bahn A. N. Extracellular streptococcal neuraminidase. J Bacteriol. 1968 Apr;95(4):1491–1492. doi: 10.1128/jb.95.4.1491-1492.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. SCHEIDEGGER J. J. Une micro-méthode de l'immuno-electrophorèse. Int Arch Allergy Appl Immunol. 1955;7(2):103–110. [PubMed] [Google Scholar]
  17. SEELEMANN M., OBIGER G. ZUR DIAGNOSE UND NOMENKLATUR DER STREPTOKOKKEN, INSBESONDERE DER VERGRUENENDEN ARTEN. Zentralbl Bakteriol Orig. 1964 May;192:434–447. [PubMed] [Google Scholar]

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