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. 2014 Sep 1;24(9):1385–1393. doi: 10.1089/thy.2014.0134

FIG. 3.

FIG. 3.

Correlation of BRAF status with tumor-infiltrating leukocytes (TILs) in papillary thyroid cancer (PTC). Mean (±standard error of the mean [SEM]) cells per high-powered field (hpf) for (A) effector and (B) suppressive immune infiltrates demonstrates greater Arginase-1+ tumor-associated macrophage and myeloid-derived suppressor cell infiltration (mean cells/hpf) in BRAFV600E compared to BRAF wild-type (BRAFWT) tumors (p<0.05). There was a trend toward both higher mean CD3+ (p=0.12) and FoxP3+ (p=0.09) cells/hpf in BRAFV600E compared to BRAFWT specimens, but no other significant finding by immune cell type. (C) Representative immunohistochemical staining of immune cell in PTC specimens, showing examples of extensive or limited immune cell infiltration. (D) In BRAFWT tumors there was a significantly higher ratio of mean CD8+ to FoxP3+ cells/hpf of 30.32±8.84 and 8.67±2.23, respectively (p<0.05) and a trend toward a higher ratio of mean CD68+ to CD163+ of 3.97±2.04 and 0.93±017, respectively (p<0.1), compared to BRAFV600E PTC specimens.