Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Sep 1;24(9):1385–1393. doi: 10.1089/thy.2014.0134

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright 2014, Mary Ann Liebert, Inc.

PMC Copyright notice

FIG. 3. — Correlation of BRAF status with tumor-infiltrating leukocytes (TILs) in papillary thyroid cancer (PTC). Mean (±standard error of the mean [SEM]) cells per high-powered field (hpf) for (A) effector and (B) suppressive immune infiltrates demonstrates greater Arginase-1⁺ tumor-associated macrophage and myeloid-derived suppressor cell infiltration (mean cells/hpf) in BRAF^V600E compared to BRAF wild-type (BRAF^WT) tumors (p<0.05). There was a trend toward both higher mean CD3⁺ (p=0.12) and FoxP3⁺ (p=0.09) cells/hpf in BRAF^V600E compared to BRAF^WT specimens, but no other significant finding by immune cell type. (C) Representative immunohistochemical staining of immune cell in PTC specimens, showing examples of extensive or limited immune cell infiltration. (D) In BRAF^WT tumors there was a significantly higher ratio of mean CD8⁺ to FoxP3⁺ cells/hpf of 30.32±8.84 and 8.67±2.23, respectively (p<0.05) and a trend toward a higher ratio of mean CD68⁺ to CD163⁺ of 3.97±2.04 and 0.93±017, respectively (p<0.1), compared to BRAF^V600E PTC specimens.