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. 1974 Feb;9(2):377–383. doi: 10.1128/iai.9.2.377-383.1974

CAMP Factor of Group B Streptococci: Production, Assay, and Neutralization by Sera from Immunized Rabbits and Experimentally Infected Cows

J Brown 1, R Farnsworth 1, L W Wannamaker 1, D W Johnson 1
PMCID: PMC414812  PMID: 4816463

Abstract

Quantitative assay methods for CAMP factor activity of group B streptococci and for neutralization of this activity by animal sera are described. The course of the CAMP reaction is influenced by preincubation of red cells with staphylococcal beta-hemolysin and the rate of the reaction by the concentration of CAMP factor. The production of CAMP factor is enhanced by substitution of maltose for glucose in culture broth. Rising inhibitory titers to CAMP activity in sera of rabbits injected with sterile culture supernates of group B streptococci suggest that CAMP factor is an antigen in the rabbit. Cows with experimentally induced group B streptococcal mastitis also demonstrated significant rises in neutralizing titers for CAMP activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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