Abstract
A study using the electron microscope was conducted with the objective of comparing the efficiency of phagocytosis and the subsequent fate of the vaccinia virus in immune and nonimmune rabbit macrophages. Although immune rabbit macrophages inhibited viral replication, they did not differ from permissive nonimmune rabbit macrophages in their ability to ingest the virus. In addition, the immune cells processed the vaccinia virus through the first stage of uncoating as evidenced by the observation of viral cores in the cell cytoplasm. These data support the thesis that the failure of vaccinia replication in immune macrophages is a function of intracellular mechanisms which operate at some point in the replicative sequence after the first stage of uncoating.
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- Avila F. R., Schultz R. M., Tompkins W. A. Specific macrophage immunity to vaccinia virus: macrophage-virus interaction. Infect Immun. 1972 Jul;6(1):9–16. doi: 10.1128/iai.6.1.9-16.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DALES S., KAJIOKA R. THE CYCLE OF MULTIPLICATION OF VACCINIA VIRUS IN EARLE'S STRAIN L CELLS. I. UPTAKE AND PENETRATION. Virology. 1964 Nov;24:278–294. doi: 10.1016/0042-6822(64)90167-9. [DOI] [PubMed] [Google Scholar]
- Dales S. Pentration of animal viruses into cells. Prog Med Virol. 1965;7:1–43. [PubMed] [Google Scholar]
- Silverstein S. Macrophages and viral immunity. Semin Hematol. 1970 Apr;7(2):185–214. [PubMed] [Google Scholar]
- Tompkins W. A., Zarling J. M., Rawls W. E. In vitro assessment of cellular immunity to vaccinia virus: contribution of lymphocytes and macrophages. Infect Immun. 1970 Dec;2(6):783–790. doi: 10.1128/iai.2.6.783-790.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]