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. 1974 Apr;9(4):696–701. doi: 10.1128/iai.9.4.696-701.1974

Effect of Tetanolysin on Platelets and Lysosomes

Claire B Cox 1, Carolyn Hardegree 1, Ralph Fornwald 1
PMCID: PMC414868  PMID: 4595758

Abstract

Tetanolysin, partially purified, caused the lysis of human and rabbit platelets, as determined by a decrease in the optical density of platelet suspensions and the release of serotonin, enzymes, and protein. This lytic activity was neutralized by antitoxin. In addition, a suspension of the lysosome-containing large granule fraction of rabbit liver released hydrolytic enzymes when exposed to tetanolysin. Thus, tetanolysin can be added to the list of bacterial toxins that are lytic for a variety of cellular or subcellular membranes. These findings provide additional data that suggest that tetanolysin may contribute to the pathogenesis of some of the unusual manifestations observed in clinical tetanus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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