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. 1974 Jul;10(1):25–29. doi: 10.1128/iai.10.1.25-29.1974

Phagocytosis of Live Versus Heat-Killed Bacteria by Human Polymorphonuclear Leukocytes

Lawrence R DeChatelet 1, Debra Mullikin 1, Pamela S Shirley 1, Charles E McCall 1
PMCID: PMC414951  PMID: 4210332

Abstract

Heat-killed Pseudomonas aeruginosa are phagocytized much more slowly by human polymorphonuclear leukocytes than are the live organisms. The post-phagocytic increase in hexose monophosphate shunt activity (HMS) parallels the ingestion of the bacteria. The addition of serum to the live organisms causes a marked increase in both ingestion and cellular HMS activity; serum actually causes an inhibition of both uptake and HMS activity when added to the heat-killed organisms. Differences in postphagocytic HMS activity between live and heat-killed organisms were observed with three different species of bacteria, indicating that the phenomenon is not restricted to P. aeruginosa. These data emphasize that the influence of the particle on the phagocytic process is considerable.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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