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Inhibitory effects on the proliferation of cells in culture
| Compd | IC50 (μM)* | ||||
|---|---|---|---|---|---|
| L1210 | CEM | HeLa | PC-3 | Caki-1 | |
| 2a | 172 ± 47 | 182 ± 20 | 7.4 ± 2.2 | 0.92 ± 0.67 | 116 ± 23 |
| 2b | 125 ± 28 | ≥250 | 143 ± 4 | 76 ± 10 | 132 ± 30 |
| 2c | 0.92 ± 0.04 | 115 ± 28 | 1.8 ± 0.2 | 3.4 ± 0.9 | 116 ± 23 |
| 2d | 5.5 ± 1.5 | 109 ± 16 | 9.4 ± 3.0 | 5.6 ± 3.3 | 98 ± 10 |
| 9a | >250 | 221 ± 0 | 201 ± 44 | 115 ± 20 | 150 ± 33 |
| 9b | >250 | >250 | 161 ± 10 | 110 ± 31 | ≥250 |
| 9c | >250 | >250 | >250 | 45 ± 26 | >250 |
50% inhibitory concentration
