Skip to main content
Infection and Immunity logoLink to Infection and Immunity
. 1974 Jul;10(1):277–279. doi: 10.1128/iai.10.1.277-279.1974

Further Study on Neutralization of Biochemical Activity of Cord Factor by Anti-Cord Factor Antibody

Masahiko Kato 1
PMCID: PMC414989  PMID: 4276350

Abstract

The action of trehalose-6, 6′-dimycolate (cord factor) of Mycobacterium tuberculosis to induce site II-specific inhibition of mitochondrial oxidative phosphorylation and to stimulate adenosine triphosphatase activity was neutralized by its specific antibody. The activity was restored after dissociation of cord factor from the immune complex.

Full text

PDF
277

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Kato M., Asselineau J. Chemical structure and biochemical activity of cord factor analogs. 6,6'-Dimycoloyl sucrose and methyl 6-mycoloyl- -D-glucoside. Eur J Biochem. 1971 Oct 14;22(3):364–370. doi: 10.1111/j.1432-1033.1971.tb01553.x. [DOI] [PubMed] [Google Scholar]
  2. Kato M., Maeda J. Isolation and biochemical activities of trehalose-6-monomycolate of Mycobacterium tuberculosis. Infect Immun. 1974 Jan;9(1):8–14. doi: 10.1128/iai.9.1.8-14.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Kato M. Site II-specific inhibition of mitochondria oxidative phosphorylation by trehalose-6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis. Arch Biochem Biophys. 1970 Oct;140(2):379–390. doi: 10.1016/0003-9861(70)90079-2. [DOI] [PubMed] [Google Scholar]
  4. Kato M. Site of action of lipid A on mitochondria. J Bacteriol. 1972 Oct;112(1):268–275. doi: 10.1128/jb.112.1.268-275.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kato M. Studies of a biochemical lesion in experimental tuberculosis in mice. 8. Effect of derivatives and chemical analogues of cord factor on structure and function of mouse liver mitochondria. Am Rev Respir Dis. 1968 Oct;98(4):668–676. doi: 10.1164/arrd.1968.98.4.668. [DOI] [PubMed] [Google Scholar]
  6. Kato M. Studies of a biochemical lesion in experimental tuberculosis in mice. VII. Structural and functional damage in mouse liver mitochondria under the toxic action of cord factor. Am Rev Respir Dis. 1968 Aug;98(2):260–269. doi: 10.1164/arrd.1968.98.2.260. [DOI] [PubMed] [Google Scholar]
  7. Kekwick R. A. The serum proteins in multiple myelomatosis. Biochem J. 1940 Sep;34(8-9):1248–1257. doi: 10.1042/bj0341248. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. NOLL H., BLOCH H. Studies on the chemistry of the cord factor of Mycobacterium tuberculosis. J Biol Chem. 1955 May;214(1):251–265. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES