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. 1975 Jan;11(1):146–151. doi: 10.1128/iai.11.1.146-151.1975

Phagocytosis of Francisella tularensis by Rhesus monkey peripheral leukocytes.

R A Proctor, J D White, E Ayala, P G Canonico
PMCID: PMC415038  PMID: 234911

Abstract

Phagocytosis of Francisella tularensis by rhesus monkey peripheral neutrophils (PMN, was assessed by autoradiography, electron microscopy, and biochemical techniques. PMN, in contrast to mononuclear phagocytes, were unable to phagocytize F. tularensis in vitro in the absence of immune serum. It is postulated that in the nonimmune host the innate inability of PMN to phagocytize F. tularensis deletes one of the possible mechanisms of host defense to bacterial infection and thus permits the early dissemination of F. tularensis to intracellular sites of specific target tissues.

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Selected References

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  1. BROOKS L., OLKEN H. G. AN AUTOMATED FLUOROMETRIC METHOD FOR DETERMINATION OF LACTIC DEHYDROGENASE IN SERUM. Clin Chem. 1965 Aug;11:748–762. [PubMed] [Google Scholar]
  2. Canonico P. G., Bird J. W. Lysosomes in skeletal muscle tissue. Zonal centrifugation evidence for multiple cellular sources. J Cell Biol. 1970 May;45(2):321–333. doi: 10.1083/jcb.45.2.321. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Claflin J. L., Larson C. L. Infection-immunity in tularemia: specificity of cellular immunity. Infect Immun. 1972 Mar;5(3):311–318. doi: 10.1128/iai.5.3.311-318.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Farquhar M. G., Bainton D. F., Baggiolini M., de Duve C. Cytochemical localization of acid phosphatase activity in granule fractions from rabbit polymorphonuclear leukocytes. J Cell Biol. 1972 Jul;54(1):141–156. doi: 10.1083/jcb.54.1.141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. KARNOVSKY M. L. Metabolic basis of phagocytic activity. Physiol Rev. 1962 Jan;42:143–168. doi: 10.1152/physrev.1962.42.1.143. [DOI] [PubMed] [Google Scholar]
  6. Klebanoff S. J. Intraleukocytic microbicidal defects. Annu Rev Med. 1971;22:39–62. doi: 10.1146/annurev.me.22.020171.000351. [DOI] [PubMed] [Google Scholar]
  7. McGavran M. H., White J. D., Eigelsbach H. T., Kerpsack R. W. Morphologic and Immunohistochemical Studies of the Pathogenesis of Infection and Antibody Formation Subsequent to Vaccination of Macaca irus with an Attenuated Strain of Pasteurella tularensis: I. Intracutaneous Vaccination. Am J Pathol. 1962 Sep;41(3):259–271. [PMC free article] [PubMed] [Google Scholar]
  8. Mickenberg I. D., Root R. K., Wolff S. M. Leukocytic function in hypogammaglobulinemia. J Clin Invest. 1970 Aug;49(8):1528–1538. doi: 10.1172/JCI106370. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Nutter J. E., Myrvik Q. N. In vitro interactions between rabbit alveolar macrophages and Pasteurella tularensis. J Bacteriol. 1966 Sep;92(3):645–651. doi: 10.1128/jb.92.3.645-651.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Paul B. B., Strauss R. R., Jacobs A. A., Sbarra A. J. Function of h(2)o(2), myeloperoxidase, and hexose monophosphate shunt enzymes in phagocytizing cells from different species. Infect Immun. 1970 Apr;1(4):338–344. doi: 10.1128/iai.1.4.338-344.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Quie P. G., White J. G., Holmes B., Good R. A. In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood. J Clin Invest. 1967 Apr;46(4):668–679. doi: 10.1172/JCI105568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. SKOOG W. A., BECK W. S. Studies on the fibrinogen, dextran and phytohemagglutinin methods of isolating leukocytes. Blood. 1956 May;11(5):436–454. [PubMed] [Google Scholar]
  13. Stefanye D., Tresselt H. B., Spero L. OBSERVATIONS ON THE BEHAVIOR IN VITRO OF PASTEURELLA TULARENSIS AFTER PHAGOCYTOSIS. J Bacteriol. 1961 Mar;81(3):470–473. doi: 10.1128/jb.81.3.470-473.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. THORPE B. D., MARCUS S. PHAGOCYTOSIS AND INTRACELLULAR FATE OF PASTEURELLA TULARENSIS. I. IN VITRO STUDIES WITH RABBIT PERITONEAL MONONUCLEAR PHAGOCYTES. J Immunol. 1964 Apr;92:657–663. [PubMed] [Google Scholar]
  15. THORPE B. D., MARCUS S. PHAGOCYTOSIS AND INTRACELLULAR FATE OF PASTEURELLA TULARENSIS. II. IN VITRO STUDIES WITH RABBIT ALVEOLAR AND GUINEA PIG ALVEOLAR AND PERITONEAL MONONUCLEAR PHAGOCYTES. J Immunol. 1964 Oct;93:558–565. [PubMed] [Google Scholar]
  16. Van Oss C. J., Gillman C. F. Phagocytosis as a surface phenomenon. Contact angles and phagocytosis of non-opsonized bacteria. J Reticuloendothel Soc. 1972 Sep;12(3):283–292. [PubMed] [Google Scholar]
  17. Van Oss C. J., Gillman C. F. Phagocytosis as a surface phenomenon. II. Contact angles and phagocytosis of encapsulated bacteria before and after opsonization by specific antiserum and complement. J Reticuloendothel Soc. 1972 Nov;12(5):497–502. [PubMed] [Google Scholar]
  18. WHITE J. D., ROONEY J. R., PRICKETT P. A., DERRENBACHER E. B., BEARD C. W., GRIFFITH W. R. PATHOGENESIS OF EXPERIMENTAL RESPIRATORY TULAREMIA IN MONKEYS. J Infect Dis. 1964 Jun;114:277–283. doi: 10.1093/infdis/114.3.277. [DOI] [PubMed] [Google Scholar]
  19. Weissmann G., Zurier R. B., Spieler P. J., Goldstein I. M. Mechanisms of lysosomal enzyme release from leukocytes exposed to immune complexes and other particles. J Exp Med. 1971 Sep 1;134(3 Pt 2):149s–165s. [PubMed] [Google Scholar]

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