Erratum to: Preservation of blood glucose homeostasis in slow-senescing somatotrophism-deficient mice subjected to intermittent fasting begun at middle or old age

Erratum to: Age

DOI 10.1007/s11357-014-9651-2

Tables detailing the results of statistical analyses, each of which accompany its corresponding figure panel in Figs. 2, 3, 4, 5, 6, and 7, were omitted from the original version. As those tables are integral to the comprehension and inference (as well as for potential independent interpretations) of those results, they have been appropriately inserted in this version.

Fig. 2.

Short-term IF improved dynamics of blood glucose assimilation in middle-aged GHR-KO females and old Ames Dwarf males. a AL-fed glucose tolerance test (absolute values, with statistical analysis table) showing detrimental effect of KO phenotype and beneficial effects of short-term IF diet on both middle-aged N and middle-aged KO female mice. b Fasted glucose tolerance test (absolute values, with statistical analysis table) showing beneficial effects of short-term IF diet on both middle-aged N and middle-aged KO female mice. c AL-fed glucose tolerance test (absolute values, with statistical analysis table) showing beneficial effect of IF diet on old N littermate control male mice. d Fasted glucose tolerance test (absolute values, with statistical analysis table) showing detrimental effect of Df phenotype, and beneficial effect of IF diet on old Df male mice. All measures of central tendency are arithmetic means, and all depictions of variation (error bars) represent standard deviations (SD) (see also Figs. S1–S8)

Fig. 3.

Short-term IF improved kinetics of insulin-mediated blood glucose clearance in middle-aged GHR-KO females and old Ames Dwarf males, and decreased gluconeogenesis in middle-aged GHR-KO females. a Insulin tolerance test (normalized values, with statistical analysis table) showing beneficial effect of KO phenotype and a combined sensitizing effect of both factors on middleaged N littermate control females. b Insulin tolerance test (normalized values, with statistical analysis table) showing sensitizing effect of Df phenotype, sensitizing effects of IF on both old N males and old Df mutant males, and a combined sensitizing effect of both factors on old N males. c Pyruvate conversion test (normalized values, with statistical analysis table) showing promoting effect of KO phenotype and repressive effects of short-term IF diet on both middle-aged N and middle-aged KO females. d Pyruvate conversion test (normalized values, with statistical analysis table) showing promoting effect of Df phenotype. All measures of central tendency are arithmetic means, and all depictions of variation (error bars) represent standard deviations (SD) (see also Figs. S9–S16)

Fig. 4.

Differential effects of phenotype or diet on AL-fed or fasted blood glucose concentrations at middle-aged (for GHR-KO Mice) or old (for Ames Dwarfs) age range. a AL-fed testing of middleaged GHR-KO female mice after short-term IF (with statistical analysis table) showing blood glucose-lowering effects of IF diet for both middle-aged N female littermate mice and middle-aged female KO mutants, and an additive (lowering) effect of KO phenotype and IF diet on middle-aged N female littermate controls. b Fasted assessment of middle-aged GHR-KO females after shortterm IF (with statistical analysis table) exhibiting blood glucose-increasing effects of IF diet for both middle-aged N female littermates and middle-aged KO female mutants. c AL-fed testing of old Ames Dwarf male mice after short-term IF (with statistical analysis table) displaying blood glucose-lowering effect of IF diet on old N littermatemales. d Fasted assessment of old Ames Dwarf males after short-term IF (with statistical analysis table) demonstrating blood glucose-lowering effect of Df phenotype as well as beneficial effect of IF diet on old N littermate males. All measures of central tendency are arithmetic means, and all depictions of variation (error bars) represent standard deviations (SD)

Fig. 5.

Longer-term IF sustained improved dynamics of blood glucose incorporation in old GHR-N females, but worsened it in old GHR-KO females and oldest-old Ames Dwarf males. a ALfed glucose tolerance test (absolute values, with statistical analysis table) showing detrimental effect of KO phenotype. b Fasted glucose tolerance test (absolute values, with statistical analysis table) showing detrimental effect of KO phenotype and beneficial effect of IF diet for old littermate control (N) female mice, yet a detrimental effect of IF for old female GHR-KO mice. c AL-fed glucose tolerance test (absolute values, with statistical analysis table) showing detrimental effect of IF diet for oldest-old Ames Dwarf mutant males. d Fasted glucose tolerance test (absolute values, with statistical analysis table) showing detrimental effect of Df phenotype and deleterious effect of IF diet on oldest-old Df mutant males. All measures of central tendency are arithmetic means, and all depictions of variation (error bars) represent standard deviations (SD) (see also Figs. S17–S28.)

Fig. 6.

Longer-term IF sustained improved kinetics of insulinmediated blood glucose clearance and gluconeogenesis in Old GHR-KOfemales, but largely desensitized oldest-oldAmesDwarf males to insulin’s effects on blood glucose. a The 1.0 USPU insulin tolerance test (normalized values, with statistical analysis table) showing a combined (sensitizing) effect of both KO phenotype and IF diet on old N female littermates. b The 0.3 USPU insulin tolerance test (normalized values, with statistical analysis table) showing sensitizing effect of KO phenotype, sensitizing effects of IF diet on both old female N controls and old female KO mutants, and sensitizing benefit of both KO phenotype and IF diet on old female N littermates. c The 0.1 USPU insulin tolerance test (normalized values, with statistical analysis table) showing sensitizing effect of KO phenotype, sensitizing effects of IF diet on both old female N mice and old female KO mutants, and sensitization benefit of both KO phenotype and IF diet on old N females. d The 1.0 USPU insulin tolerance test (normalized values, with statistical analysis table) showing de-sensitizing effect of Df phenotype, de-sensitizing effect of IF diet on oldest-old N males, yet sensitizing effect of IF on oldest-old Df male mice. e The 0.3 USPU insulin tolerance test (normalized values, with statistical analysis table) showing de-sensitizing effects of IF on both oldestold N male mice and oldest-old male Df mutants, as well as desensitizing effect of a combination of both factors on oldest-old N littermate control males. f The 0.1 USPU insulin tolerance test (normalized values, with statistical analysis table) showing desensitizing effect of Df phenotype and de-sensitizing effect of IF on oldest-old N littermate males. g Pyruvate conversion test (normalized values, with statistical analysis table) showing promoting effect of Ghr/bp gene disruption and repressive effect of IF diet for female GHR-KO mice. h Pyruvate conversion test (normalized values, with statistical analysis table) showing no effect of either Df phenotype or IF on oldest-old males of either phenotype. All measures of central tendency are arithmetic means, and all depictions of variation (error bars) represent standard deviations (SD) (see also Figs. S29–S40)

Fig. 7.

Differential effects of phenotype or diet on AL-fed or fasted blood glucose concentrations at old (for GHR-KO mice) or oldestold (forAmes Dwarfs) age range. a AL-fed testing of old GHR-KO female mice after longer-term IF (with statistical analysis table) showing blood glucose-lowering effect of a combination of KO phenotype and IF diet for old KO littermate control females. b Fasted assessment of old GHR-KO females after longer-term IF (with statistical analysis table) exhibiting no blood-glucose lowering effect of either KO phenotype, IF diet, or combination of KO phenotype and IF diet. c AL-fed testing of oldest-old Ames Dwarf male mice after longer-term IF (with statistical analysis table) displaying no blood glucose-lowering effect of either Df phenotype, IF diet, or combination of the two factors. d Fasted assessment of oldest-old Ames Dwarf male mice after longer-term IF (with statistical analysis table) demonstrating no blood glucose-lowering effect of either Df phenotype, IF diet, or combination of the two. All measures of central tendency are arithmetic means, and all depictions of variation (error bars) represent standard deviations (SD)