Abstract
Acid-base alterations in Streptococcus pneumoniae infection were studied in 80 male albino rats. Hematocrit and concentrations of plasma electrolytes, glucose, and total protein were also measured. At 3-h intervals throughout a 27-h study, four control and four infected rats were anesthetized with ether, and blood samples were taken. Arterial blood pH, Po2, and hematocrit increased in the infected group, whereas arterial Pco2, HCO3-, and venous Po2 decreased. Plasma K+ concentration increased slightly and glucose levels decreased in the infected rats as the sepsis progressed. No significant changes were observed in venous blood pH, HCO3-, and Pco2. Plasma Na+, Cl-, and total protein remained unchanged. The increase in arterial blood pH and decrease in arterial Pco2 and HCO3- indicated respiratory alkalosis, which was present in rats infected with S. pneumoniae.
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Selected References
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- Beisel W. R., Goldman R. F., Joy R. J. Metabolic balance studies during induced hyperthermia in man. J Appl Physiol. 1968 Jan;24(1):1–10. doi: 10.1152/jappl.1968.24.1.1. [DOI] [PubMed] [Google Scholar]
- Burger F. J., Engelbrecht F. M., Jordaan E. M., Bester P. Studies on the blood composition of hyperthermic animals. S Afr Med J. 1970 May 2;44(18):524–528. [PubMed] [Google Scholar]
- COTLOVE E., TRANTHAM H. V., BOWMAN R. L. An instrument and method for automatic, rapid, accurate, and sensitive titration of chloride in biologic samples. J Lab Clin Med. 1958 Mar;51(3):461–468. [PubMed] [Google Scholar]
- Dick T. B., Gemmell C. G. The pathogenesis of pneumococcal infection in mice. J Med Microbiol. 1971 May;4(2):153–163. doi: 10.1099/00222615-4-2-153. [DOI] [PubMed] [Google Scholar]
- IAMPIETRO P. F., MAGER M., GREEN E. B. Some physiological changes accompanying tetany induced by exposure to hot, wet conditions. J Appl Physiol. 1961 May;16:409–412. doi: 10.1152/jappl.1961.16.3.409. [DOI] [PubMed] [Google Scholar]
- KANTER G. S. Cause of hypophosphatemia in hyperthermic dogs. Am J Physiol. 1960 Aug;199:261–264. doi: 10.1152/ajplegacy.1960.199.2.261. [DOI] [PubMed] [Google Scholar]
- KANTER G. S. Effect of heat on regulation of body fluids and electrolytes in dogs. Am J Physiol. 1954 Aug;178(2):259–262. doi: 10.1152/ajplegacy.1954.178.2.259. [DOI] [PubMed] [Google Scholar]
- Mitruka B. M. Biochemical aspects of Diplococcus pneumoniae infections in laboratory rats. Yale J Biol Med. 1971 Dec;44(3):253–264. [PMC free article] [PubMed] [Google Scholar]
- PERRY J. E., CLUFF L. E. MANIFESTATIONS OF FATAL PNEUMOCOCCAL INFECTION IN RABBITS. J Lab Clin Med. 1963 Oct;62:549–558. [PubMed] [Google Scholar]
- Perry J. E., Cluff L. E. Clinical and bacteriological events in experimental lethal pneumococcal infection. Tex Rep Biol Med. 1966 Spring;24(1):125–140. [PubMed] [Google Scholar]
- Sudduth N. C., Widish J. R., Moore J. L. Automation of glucose measurement using ortho-toluidine reagent: comparison of values determined by automated ferricyanide and ortho-toluidine methods. Am J Clin Pathol. 1970 Feb;53(2):181–189. doi: 10.1093/ajcp/53.2.181. [DOI] [PubMed] [Google Scholar]