Abstract
Serum samples from patients with many different kinds of infection were shown to contain a substance characteristic of leukocytic endogenous mediator. Generalized bacterial infections produced more leukocytic endogenous mediator than did localized ones; viral infections produced very little. In typhoid fever, mediator concentrations increased before the onset of illness.
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Selected References
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- Dolin R., Blacklow N. R., DuPont H., Formal S., Buscho R. F., Kasel J. A., Chames R. P., Hornick R., Chanock R. M. Transmission of acute infectious nonbacterial gastroenteritis to volunteers by oral administration of stool filtrates. J Infect Dis. 1971 Mar;123(3):307–312. doi: 10.1093/infdis/123.3.307. [DOI] [PubMed] [Google Scholar]
- DuPont H. L., Formal S. B., Hornick R. B., Snyder M. J., Libonati J. P., Sheahan D. G., LaBrec E. H., Kalas J. P. Pathogenesis of Escherichia coli diarrhea. N Engl J Med. 1971 Jul 1;285(1):1–9. doi: 10.1056/NEJM197107012850101. [DOI] [PubMed] [Google Scholar]
- DuPont H. L., Hornick R. B., Snyder M. J., Libonati J. P., Formal S. B., Gangarosa E. J. Immunity in shigellosis. II. Protection induced by oral live vaccine or primary infection. J Infect Dis. 1972 Jan;125(1):12–16. doi: 10.1093/infdis/125.1.12. [DOI] [PubMed] [Google Scholar]
- Hornick R. B., Greisman S. E., Woodward T. E., DuPont H. L., Dawkins A. T., Snyder M. J. Typhoid fever: pathogenesis and immunologic control. N Engl J Med. 1970 Sep 24;283(13):686–691. doi: 10.1056/NEJM197009242831306. [DOI] [PubMed] [Google Scholar]
- Kampschmidt R. F., Upchurch H. F., Eddington C. L., Pulliam L. A. Multiple biological activities of a partially purified leukocytic endogenous mediator. Am J Physiol. 1973 Mar;224(3):530–533. doi: 10.1152/ajplegacy.1973.224.3.530. [DOI] [PubMed] [Google Scholar]
- Pekarek R. S., Beisel W. R., Bartelloni P. J., Bostian K. A. Determination of serum zinc concentrations in normal adult subjects by atomic absorption spectrophotometry. Am J Clin Pathol. 1972 Apr;57(4):506–510. doi: 10.1093/ajcp/57.4.506. [DOI] [PubMed] [Google Scholar]
- Pekarek R. S., Wannemacher R. W., Jr, Chapple F. E., 3rd, Powanda M. C., Beisel W. R. Further characterization and species specificity of leukocytic endogenous mediator (LEM). Proc Soc Exp Biol Med. 1972 Nov;141(2):643–648. doi: 10.3181/00379727-141-36842. [DOI] [PubMed] [Google Scholar]
- Wannemacher R. W., Jr, DuPont H. L., Pekarek R. S., Powanda M. C., Schwartz A., Hornick R. B., Beisel W. R. An endogenous mediator of depression of amino acids and trace metals in serum during typhoid fever. J Infect Dis. 1972 Jul;126(1):77–86. doi: 10.1093/infdis/126.1.77. [DOI] [PubMed] [Google Scholar]
- Wannemacher R. W., Jr, Pekarek R. S., Beisel W. R. Mediator of hepatic amino acid flux in infected rats. Proc Soc Exp Biol Med. 1972 Jan;139(1):128–132. doi: 10.3181/00379727-139-36094. [DOI] [PubMed] [Google Scholar]
- Wannemacher R. W., Jr, Pekarek R. W., Bartelloni P. J., Vollmer R. T., Beisel W. R. Changes in individual plasma amino acids following experimentally induced and fly fever virus infection. Metabolism. 1972 Jan;21(1):67–76. doi: 10.1016/0026-0495(72)90021-2. [DOI] [PubMed] [Google Scholar]