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. 1975 May;11(5):886–889. doi: 10.1128/iai.11.5.886-889.1975

Effect of cyclophosphamide on infections in mice caused by virulent and avirulent strains of influenza virus.

J Hurd, R B Heath
PMCID: PMC415152  PMID: 1168172

Abstract

Induced immunosuppression with the drug cyclophosphamide was shown to convert the relatively harmless infection with an avirulent strain of Kunz influenza virus into a fatal pneumonic illness. The drug was also shown to increase the mortality of mice infected with low concentrations of a virulent variant of this strain, but it delayed the time of death of mice that were infected with high concentrations ofthe same variant. The probable roles of immune and inflammatory mechanisms in recovery from primary influenza virus infections are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERLIN B. S. SPARING EFFECT OF X-RAYS FOR MICE INOCULATED INTRANASALLY WITH EGG-ADAPTED INFLUENZA VIRUS, CAM STRAIN. Proc Soc Exp Biol Med. 1964 Dec;117:864–869. doi: 10.3181/00379727-117-29720. [DOI] [PubMed] [Google Scholar]
  2. Cole G. A., Nathanson N. Potentiation of experimental arbovirus encephalitis by immunosuppressive doses of cyclophosphamide. Nature. 1968 Oct 26;220(5165):399–401. doi: 10.1038/220399a0. [DOI] [PubMed] [Google Scholar]
  3. Hirsch M. S., Murphy F. A. Effects of anti-lymphoid sera on viral infections. Lancet. 1968 Jul 6;2(7558):37–40. doi: 10.1016/s0140-6736(68)92904-8. [DOI] [PubMed] [Google Scholar]
  4. Robinson T. W., Cureton R. J., Heath R. B. The effect of cyclophosphamide on Sendai virus infection of mice. J Med Microbiol. 1969 May;2(2):137–145. doi: 10.1099/00222615-2-2-137. [DOI] [PubMed] [Google Scholar]
  5. Robinson T. W., Cureton R. J., Heath R. B. The pathogenesis of Sendai virus infection in the mouse lung. J Med Microbiol. 1968 Aug;1(1):89–95. doi: 10.1099/00222615-1-1-89. [DOI] [PubMed] [Google Scholar]
  6. Singer S. H., Ford M., Kirschstein R. L. Respiratory diseases in cyclophosphamide-treated mice. I. Increased virulence of Mycoplasma pulmonis. Infect Immun. 1972 Jun;5(6):953–956. doi: 10.1128/iai.5.6.953-956.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Singer S. H., Noguchi P., Kirschstein R. L. Respiratory diseases in cyclophosphamide-treated mice. II. Decreased virulence of PR8 influenza virus. Infect Immun. 1972 Jun;5(6):957–960. doi: 10.1128/iai.5.6.957-960.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]

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