Abstract
The replication of mumps virus in susceptible chicken embryonic heart cells was escalated by daily treatment of cultures with 6-azauridine (6-AU). On the other hand, virus production by less susceptible liver cells was depressed by 6-AU. The population of infected susceptible cells was not increased, but the release of virus by infected susceptible cells was enhanced 20-fold by 10 mug of 6-AU per ml. Less susceptible cells, which incorporated less ribonucleic acid and protein precursor than susceptible cells, sustained a constant level of viral release during 6-AU treatment; however, the number of infected less susceptible cells underwent substantial decline.
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Selected References
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- Davis C. W., St Geme J. W., Jr A rapid hemadsorption plaque assay for mumps virus. Proc Soc Exp Biol Med. 1971 Apr;136(4):1319–1322. doi: 10.3181/00379727-136-35483. [DOI] [PubMed] [Google Scholar]
- HANDSCHUMACHER R. E. Orotidylic acid decarboxylase: inhibition studies with azauridine 5'-phosphate. J Biol Chem. 1960 Oct;235:2917–2919. [PubMed] [Google Scholar]
- Kingsbury D. W. Paramyxovirus replication. Curr Top Microbiol Immunol. 1972;59:1–33. doi: 10.1007/978-3-642-65444-2_1. [DOI] [PubMed] [Google Scholar]
- Northrop R. L. Effect of puromycin and actinomycin D on a persistent mumps virus infection in vitro. J Virol. 1969 Aug;4(2):133–140. doi: 10.1128/jvi.4.2.133-140.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Portner A., Bussell R. H. Measles virus ribonucleic acid and protein synthesis: effects of 6-azauridine and cycloheximide on viral replication. J Virol. 1973 Jan;11(1):46–53. doi: 10.1128/jvi.11.1.46-53.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- St Geme J. W., Jr, Davis C. W., Martin H. L. Comparative production of paramyxoviruses by avian heart cells. J Gen Virol. 1974 Oct;25(1):163–166. doi: 10.1099/0022-1317-25-1-163. [DOI] [PubMed] [Google Scholar]
- ter Meulen V., Leonard L. L., Lennette E. H., Katz M., Koprowski H. The effect of 6-azauridine upon subacute sclerosing panencephalitis virus in tissue cultures. Proc Soc Exp Biol Med. 1972 Jul;140(3):1111–1115. doi: 10.3181/00379727-140-36622. [DOI] [PubMed] [Google Scholar]