Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1975 May;11(5):1031–1037. doi: 10.1128/iai.11.5.1031-1037.1975

Immunodepression by Rowson-Parr virus in mice: effect of Rowson-Parr virus and Friend leukemia complex infections on contact sensitivity in susceptible and resistant mice.

M Bendinelli, M Campa, A Toniolo
PMCID: PMC415176  PMID: 1123252

Abstract

Contact sensitivity to 2-phenyl-4-ethoxymethilene oxazolone, as a probe for cell-mediated immunity, was investigated in susceptible BALB/c and resistant C57BL/6 mice after infection with Friend leukemia complex (FLC) or with Rowson-Parr virus (RPV). In BALB/c mice, FLC depressed contact sensitivity when given before primary sensitization but had no effect on established contact sensitivity nor on the response elicited by a booster application of the sensitizer. These findings, together with the failure to alter reactivity to an aspecific inflammatory stimulus, indicate that FLC impairs the afferent limb of the response. In the same strain of mice RPV infection did not significantly depress contact sensitivity, as judged by the extent of the reaction 24 h after challenge, but slightly inhibited the early antibody-mediated phase of this reaction. In C57BL/6 mice neither viral preparation affected contact sensitivity.

Full text

PDF
1031

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asherson G. L., Barnes R. M. Contact sensitivity in the mouse. IX. The role of immunological and non-immunological inflammation in the movement of lymphocytes to immunized lymph nodes. Immunology. 1973 May;24(5):885–894. [PMC free article] [PubMed] [Google Scholar]
  2. Asherson G. L., Ptak W. Contact and delayed hypersensitivity in the mouse. I. Active sensitization and passive transfer. Immunology. 1968 Sep;15(3):405–416. [PMC free article] [PubMed] [Google Scholar]
  3. Asherson G. L., Zembala M. Anatomical location of cells which mediate contact sensitivity in the lympho nodes and bone marrow. Nat New Biol. 1973 Aug 8;244(136):176–177. doi: 10.1038/newbio244176a0. [DOI] [PubMed] [Google Scholar]
  4. Asherson G. L., Zembala M. Contact sensitivity in the mouse. IV. The role of lymphocytes and macrophages in passive transfer and the mechanism of their interaction. J Exp Med. 1970 Jul 1;132(1):1–15. doi: 10.1084/jem.132.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bainbridge D. R., Bendinelli M. Circulation of lymphoid cells in mice infected with Friend leukemia virus. J Natl Cancer Inst. 1972 Sep;49(3):773–781. [PubMed] [Google Scholar]
  6. Bendinelli M. Haemolytic plaque formation by mouse peritoneal cells, and the effect on it of Friend virus infection. Immunology. 1968 Jun;14(6):837–850. [PMC free article] [PubMed] [Google Scholar]
  7. Bendinelli M., Nardini L. Immunodepression by Rowson-Parr virus in mice. I. Growth curves of Rowson-Parr virus and immunological relationships with Friend virus. Infect Immun. 1973 Feb;7(2):152–159. doi: 10.1128/iai.7.2.152-159.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bendinelli M., Nardini L. Immunodepression by Rowson-Parr virus in mice. II. Effect of Rowson-Parr virus infection on the antibody response to sheep red cells in vivo and in vitro. Infect Immun. 1973 Feb;7(2):160–166. doi: 10.1128/iai.7.2.160-166.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Bennett M., Steeves R. A. Immunocompetent cell functions in mice infected with Friend leukemia virus. J Natl Cancer Inst. 1970 May;44(5):1107–1119. [PubMed] [Google Scholar]
  10. Carter R. L., Chesterman F. C., Rowson K. E., Salaman M. H., Wedderburn N. A new virus of minimal pathogenicity associated with Friend virus. II. Histological changes and immunodepressive effect. Int J Cancer. 1970 Jan 15;5(1):103–110. doi: 10.1002/ijc.2910050114. [DOI] [PubMed] [Google Scholar]
  11. Carter R. L., Chesterman F. C., Rowson K. E., Salaman M. H., Wedderburn N. Induction of lymphoma in BALB-c mice by Rowson-Parr virus (RPV). Int J Cancer. 1970 Sep 15;6(2):290–303. doi: 10.1002/ijc.2910060217. [DOI] [PubMed] [Google Scholar]
  12. Ceglowski W. S., Campbell B. P., Mortensen R. F., Friedman H. Humoral and cellular immune responses in susceptible and resistant strains of mice infected with friend leukemia virus. Proc Soc Exp Biol Med. 1974 Jun;146(2):619–624. doi: 10.3181/00379727-146-38159. [DOI] [PubMed] [Google Scholar]
  13. Ceglowski W. S., Friedman H. Murine virus leukaemogenesis: relationship between susceptibility and immunodepression. Nature. 1969 Dec 27;224(5226):1318–1319. doi: 10.1038/2241318a0. [DOI] [PubMed] [Google Scholar]
  14. Chirigos M. A., Perk K., Turner W., Burka B., Gomez M. Increased oncogenicity of the murine sarcoma virus (Moloney) by co-infection with murine leukemia viruses. Cancer Res. 1968 Jun;28(6):1055–1063. [PubMed] [Google Scholar]
  15. Dawson P. J., Tacke R. B., Fieldsteel A. H. Relationship between Friend virus and an associated lymphatic leukaemia virus. Br J Cancer. 1968 Sep;22(3):569–576. doi: 10.1038/bjc.1968.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Dent P. B. Immunodepression by oncogenic viruses. Prog Med Virol. 1972;14:1–35. [PubMed] [Google Scholar]
  17. Fabris N. Immunological reactivity during pregnancy in the mouse. Experientia. 1973 May 15;29(5):610–612. doi: 10.1007/BF01926697. [DOI] [PubMed] [Google Scholar]
  18. Friedman H., Ceglowski W. S. Defect in cellular immunity of leukemia virus-infected mice assessed by a macrophage migration-inhibition assay. Proc Soc Exp Biol Med. 1971 Jan;136(1):154–158. doi: 10.3181/00379727-136-35216. [DOI] [PubMed] [Google Scholar]
  19. Friedman H., Melnick H., Mills L., Ceglowski W. S. Depressed allograft immunity in leukemia virus infected mice. Transplant Proc. 1973 Mar;5(1):981–986. [PubMed] [Google Scholar]
  20. Greenwood B. M., Playfair J. H., Torrigiani G. Immunosuppression in murine malaria. I. General characteristics. Clin Exp Immunol. 1971 Mar;8(3):467–478. [PMC free article] [PubMed] [Google Scholar]
  21. Griswold D. E., DiLorenzo J. A., Calabresi P. Quantification and pharmacological dissection of oxazolone-induced contact sensitivity in the mouse. Cell Immunol. 1974 Mar 30;11(1-3):198–204. doi: 10.1016/0008-8749(74)90019-7. [DOI] [PubMed] [Google Scholar]
  22. Kumar V., Bennett M., Eckner R. J. Mechanisms of genetic resistance to friend virus leukemia in mice. J Exp Med. 1974 May 1;139(5):1093–1109. doi: 10.1084/jem.139.5.1093. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. McCoy J. L., Fefer A., Glynn J. P. Comparative studies on the induction of transplantation resistance in BALB-c and C57BL-6 mice in three murine leukemia systems. Cancer Res. 1967 Oct;27(10):1743–1748. [PubMed] [Google Scholar]
  24. Mortensen R. F., Ceglowski W. S., Friedman H. Leukemia virus-induced immunosuppression. IX. Depression of delayed hypersensitivity and MIF production after infection of mice with Friend leukemia virus. J Immunol. 1973 Dec;111(6):1810–1819. [PubMed] [Google Scholar]
  25. Mortensen R. F., Ceglowski W. S., Friedman H. Leukemia virus-induced immunosuppression. X. Depression of T cell-mediated cytotoxicity after infection of mice with Friend leukemia virus. J Immunol. 1974 Jun;112(6):2077–2086. [PubMed] [Google Scholar]
  26. Mortensen R. F., Ceglowski W. S., Friedman H. Susceptibility and resistance to Friend leukemia virus: effect on production of migration-inhibition factor. J Natl Cancer Inst. 1974 Feb;52(2):499–505. doi: 10.1093/jnci/52.2.499. [DOI] [PubMed] [Google Scholar]
  27. Notkins A. L., Mergenhagen S. E., Howard R. J. Effect of virus infections on the function of the immune system. Annu Rev Microbiol. 1970;24:525–538. doi: 10.1146/annurev.mi.24.100170.002521. [DOI] [PubMed] [Google Scholar]
  28. Odaka T., Ishi H., Yamaura K., Yamamoto T. Inhibitory effect of Friend leukemia virus infection on the antibody formation to sheep erythrocytes in mice. Jpn J Exp Med. 1966 Jun;36(3):277–290. [PubMed] [Google Scholar]
  29. Parrott D. M., De Sousa M. A., Fachet J., Wallis V., Leuchars E., Davies A. J. The response of normal, thymectomized and reconstituted mice in contact sensitivity. Clin Exp Immunol. 1970 Sep;7(3):387–393. [PMC free article] [PubMed] [Google Scholar]
  30. Phanuphak P., Moorhead J. W., Claman H. N. Tolerance and contact sensitivity to DNFB in mice. I. In vivo detection by ear swelling and correlation with in vitro cell stimulation. J Immunol. 1974 Jan;112(1):115–123. [PubMed] [Google Scholar]
  31. Pritchard H., Micklem H. S. Immune responses in congenitally thymus-less mice. I. Absence of response to oxazolone. Clin Exp Immunol. 1972 Jan;10(1):151–161. [PMC free article] [PubMed] [Google Scholar]
  32. Rowson K. E., Parr I. B. A new virus of minimal pathogenicity associated with Friend virus. I. Isolation by end-point dilution. Int J Cancer. 1970 Jan 15;5(1):96–102. doi: 10.1002/ijc.2910050113. [DOI] [PubMed] [Google Scholar]
  33. Schneider M., Doré J. F. Effet de l'injection d'un virus leucémogène murin (Friend) sur les réactions immunitaires de souris sensibles et résistantes à ce virus. Rev Fr Etud Clin Biol. 1969 Dec;14(10):1010–1014. [PubMed] [Google Scholar]
  34. Steeves R. A., Eckner R. J., Bennett M., Mirand E. A., Trudel P. J. Isolation and characterization of a lymphatic leukemia virus in the Friend virus complex. J Natl Cancer Inst. 1971 Jun;46(6):1209–1217. [PubMed] [Google Scholar]
  35. Stutman O., Dupuy J. M. Resistance to Friend leukemia virus in mice: effect of immunosuppression. J Natl Cancer Inst. 1972 Nov;49(5):1283–1293. [PubMed] [Google Scholar]
  36. Wedderburn N., Salaman M. H. The immunodepressive effect of Friend virus. II. Reduction of splenic haemolysin-producing cells in primary and secondary responses. Immunology. 1968 Sep;15(3):439–454. [PMC free article] [PubMed] [Google Scholar]
  37. Wheelock E. F., Toy S. T., Weislow O. S., Levy M. H. Restored immune and nonimmune functions in Friend virus leukemic mice treated with statolon. Prog Exp Tumor Res. 1974;19:369–389. doi: 10.1159/000395867. [DOI] [PubMed] [Google Scholar]
  38. Zembala M., Asherson G. L. Contact sensitivity in the mouse. V. The role of macrophage cytophilic antibody in passive transfer and the effect of trypsin and anti-gamma globulin serum. Cell Immunol. 1970 Sep;1(3):276–289. doi: 10.1016/0008-8749(70)90049-3. [DOI] [PubMed] [Google Scholar]
  39. de Sousa M. A., Parrott D. M. Induction and recall in contact sensivitity. Changes in skin and draining lymph nodes of intact and thymectomized mice. J Exp Med. 1969 Oct 1;130(4):671–690. doi: 10.1084/jem.130.4.671. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES