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. 1975 Jun;11(6):1342–1351. doi: 10.1128/iai.11.6.1342-1351.1975

Differential Effects of Homocytotropic Antibodies on the Mast Cell and Anaphylactic Responses in Actively and Passively Sensitized Mice

John B Barnett a,1, David E Justus a
PMCID: PMC415221  PMID: 1140849

Abstract

The relationship between mast cell degranulation, anaphylaxis, and the production of homocytotropic antibodies was examined in ICR mice after trichinella infection. It was found that the active cutaneous response to trichinella antigen had a rapid onset (within 2 weeks) and the sensitivity increased over a 9-week period after infection. Two types of mast cell degranulation were observed: (i) moderate, with few extracellular, deep-blue-staining granules (May-Grunwald-Giemsa), and (ii) “explosive,” with many extracellular reddish-staining, swollen granules, indicating an apparent breakdown of cell membrane. The moderate type was observed primarily during the first 4 weeks after infection, whereas the explosive type predominated during 5 to 8 weeks. Homocytotropic antibody of the immunoglubulin G1 type appears responsible for moderate type degranulation, and mouse immunoglobulin E appears responsible for the explosive degranulation. No correlation was evident between the active cutaneous anaphylactic response and either type of degranulation or between active cutaneous anaphylaxis and circulating levels of homocytotropic antibody. A proposed role of immunoglobulin G1 and mouse immunoglobulin E in immunity is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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