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. 1975 Jul;12(1):29–35. doi: 10.1128/iai.12.1.29-35.1975

Factors in the inactivation of Encephalomyocarditis virus in aerosols.

J C de Jong, M Harmsen, T Trouwborst
PMCID: PMC415240  PMID: 166928

Abstract

Encephalomyocarditis virus in aerosols is inactivated rapidly at relative humidities below 50%. In glycerol-water mixtures a similar decrease of infectivity occurs when the glycerol concentration exceeds 78% (wt/wt), corresponding to a relative humidity of 50%. The decay in aerosols does not involve oxygen or surface-dependent factors. Variation of temperature shows the inactivation to be a low-energy process with an activation enthalpy of 15 kcal per mol. The damage could be ascribed to dehydration of the virion, presumably proceeding to removal of structurally essential water molecules. This might trigger irreversible changes in the protein coat, resulting in disintegration of the virion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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