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. 1975 Jul;12(1):76–80. doi: 10.1128/iai.12.1.76-80.1975

Depressed specific cell-mediated immunity to Herpes simplex virus type 1 in patients with recurrent herpes labialis.

Y H Thong, M M Vincent, S A Hensen, D A Fuccillo, M Rola-Pleszczynski, J A Bellanti
PMCID: PMC415247  PMID: 166930

Abstract

Cell-mediated immunity to herpes simplex virus type 1 (HSV-1) was assessed by a lymphocytotoxicity 51-Cr-release microassay procedure, using the MA-160 human prostatic adenoma cell line chronically infected with HSV-1 and its parent cell line as control. The specific immune release mean plus or minus standard deviation for nine asymptomatic patients with recurrent HSV-1 infections was 13.7 plus or minus 8.1%, compared to 28.9 plus or minus 8.4% in seven normal seropositive controls (P is less than 0.01). In four additional patients studied serially, the cell-mediated immunity was significantly increased during the recrudescence of herpetic infection, with a mean specific immune release value of 51.7 plus or minus 27.8%, compared to 8.7 plus or minus 1.5% during the convalescent period 2 to 10 weeks later (P is less than 0.05). These findings suggest that patients with recurrent HSV-1 infections have vigorous cellular immune responses during the acute phase but a specific impairment of cell-mediated immunity during the quiescent period, which may in part account for their susceptibility to recurrent herpetic infections.

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Selected References

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  1. Baringer J. R., Swoveland P. Recovery of herpes-simplex virus from human trigeminal ganglions. N Engl J Med. 1973 Mar 29;288(13):648–650. doi: 10.1056/NEJM197303292881303. [DOI] [PubMed] [Google Scholar]
  2. Bastian F. O., Rabson A. S., Yee C. L., Tralka T. S. Herpesvirus hominis: isolation from human trigeminal ganglion. Science. 1972 Oct 20;178(4058):306–307. doi: 10.1126/science.178.4058.306. [DOI] [PubMed] [Google Scholar]
  3. Bellanti J. A. Biologic significance of the secretory A immunoglobulins. Pediatrics. 1971 Nov;48(5):715–729. [PubMed] [Google Scholar]
  4. Cole G. A., Gilden D. H., Monjan A. A., Nathanson N. Lymphocytic choriomeningitis virus: pathogenesis of acute central nervous system disease. Fed Proc. 1971 Nov-Dec;30(6):1831–1841. [PubMed] [Google Scholar]
  5. Cook M. L., Stevens J. G. Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence for intra-axonal transport of infection. Infect Immun. 1973 Feb;7(2):272–288. doi: 10.1128/iai.7.2.272-288.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ennis F. A. Host defense mechanisms against Herpes simplex virus. I. Control of infection in vitro by senstized spleen cells and antibody. Infect Immun. 1973 Jun;7(6):898–904. doi: 10.1128/iai.7.6.898-904.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ennis F. A. Host defense mechanisms against herpes simplex virus. II. Protection conferred by sensitized spleen cells. J Infect Dis. 1973 Jun;127(6):632–638. doi: 10.1093/infdis/127.6.632. [DOI] [PubMed] [Google Scholar]
  8. Fraley E. E., Ecker S., Vincent M. M. Spontaneous in vitro neoplastic transformation of adult human prostatic epithelium. Science. 1970 Oct 30;170(3957):540–542. doi: 10.1126/science.170.3957.540. [DOI] [PubMed] [Google Scholar]
  9. Fuccillo D. A., Moder F. L., Catalano L. W., Jr, Vincent M. M., Sever J. L. Herpesvirus hominis types I and II: a specific microindirect hemagglutination test. Proc Soc Exp Biol Med. 1970 Mar;133(3):735–739. doi: 10.3181/00379727-133-34554. [DOI] [PubMed] [Google Scholar]
  10. Glasgow L. A. Cellular immunity in host resistance to viral infections. Arch Intern Med. 1970 Jul;126(1):125–134. [PubMed] [Google Scholar]
  11. HOGGAN M. D., ROIZMAN B., TURNER T. B. The effect of the temperature of incubation on the spread of Herpes simplex virus in an immune environment in cell culture. J Immunol. 1960 Feb;84:152–159. [PubMed] [Google Scholar]
  12. Logan W. S., Tindall J. P., Elson M. L. Chronic cutaneous herpes simplex. Arch Dermatol. 1971 Jun;103(6):606–614. [PubMed] [Google Scholar]
  13. Merigan T. C. Host defenses against viral disease. N Engl J Med. 1974 Feb 7;290(6):323–329. doi: 10.1056/NEJM197402072900608. [DOI] [PubMed] [Google Scholar]
  14. Merigan T. C., Stevens D. A. Viral infections in man associated with acquired immunological deficiency states. Fed Proc. 1971 Nov-Dec;30(6):1858–1864. [PubMed] [Google Scholar]
  15. Mori R., Tasaki T., Kimura G., Takeya K. Depression of acquired resistance against herpes simplex virus infection in neonatally thymectomized mice. Arch Gesamte Virusforsch. 1967;21(3):459–462. doi: 10.1007/BF01241745. [DOI] [PubMed] [Google Scholar]
  16. Muller S. A., Herrmann E. C., Jr, Winkelmann R. K. Herpes simplex infections in hematologic malignancies. Am J Med. 1972 Jan;52(1):102–114. doi: 10.1016/0002-9343(72)90012-5. [DOI] [PubMed] [Google Scholar]
  17. Nahmias A. J. Disseminated herpes-simplex-virus infections. N Engl J Med. 1970 Mar 19;282(12):684–685. doi: 10.1056/NEJM197003192821213. [DOI] [PubMed] [Google Scholar]
  18. Nahmias A. J. Herpesviruses from fish to man--a search for pathobiologic unity. Pathobiol Annu. 1972;2:153–182. [PubMed] [Google Scholar]
  19. Nahmias A. J., Hirsch M. S., Kramer J. H., Murphy F. A. Effect of antithymocyte serum on herpesvirus hominis (type 1) infection in adult mice. Proc Soc Exp Biol Med. 1969 Nov;132(2):696–698. doi: 10.3181/00379727-132-34290. [DOI] [PubMed] [Google Scholar]
  20. Plummer G., Hollingsworth D. C., Phuangsab A., Bowling C. P. Chronic infections by herpes simplex viruses and by the horse and cat herpesviruses. Infect Immun. 1970 Apr;1(4):351–355. doi: 10.1128/iai.1.4.351-355.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Richman A. V., Vincent M. M., Martino E. C., Tauraso N. M. Heterotransplantation of human prostatic adenoma cells, MA160, into nonimmunosuppressed hamsters. Cancer Res. 1972 Oct;32(10):2186–2189. [PubMed] [Google Scholar]
  22. Russell A. S. Cell-mediated immunity to herpes simplex virus in man. J Infect Dis. 1974 Feb;129(2):142–146. doi: 10.1093/infdis/129.2.142. [DOI] [PubMed] [Google Scholar]
  23. Russell A. S., Percy J. S., Kovithavongs T. Cell-mediated immunity to Herpes simplex in humans: lymphocyte cytotoxicity measured by 51-Cr release from infected cells. Infect Immun. 1975 Feb;11(2):355–359. doi: 10.1128/iai.11.2.355-359.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Steele R. W., Hensen S. A., Vincent M. M., Fuccillo D. A., Bellanti J. A. A 51 Cr microassay technique for cell-mediated immunity to viruses. J Immunol. 1973 Jun;110(6):1502–1510. [PubMed] [Google Scholar]
  25. Stevens J. G., Cook M. L. Latent infections induced by herpes simplex viruses. Cancer Res. 1973 Jun;33(6):1399–1401. [PubMed] [Google Scholar]
  26. Terni M. L'infezione da virus dell'herpes simplex, la malattia recidivante e il problema della latenza. G Mal Infett Parassit. 1971 Jul;23(7):433–467. [PubMed] [Google Scholar]
  27. Thorsby E. Cell specific and common antigens on human granulocytes and lymphocytes demonstrated with cytotoxic hetero-antibodies. Vox Sang. 1967 Aug;13(2):194–206. doi: 10.1111/j.1423-0410.1967.tb03949.x. [DOI] [PubMed] [Google Scholar]
  28. Wilton J. M., Ivanyi L., Lehner T. Cell-mediated immunity in Herpesvirus hominis infections. Br Med J. 1972 Mar 18;1(5802):723–726. doi: 10.1136/bmj.1.5802.723. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Zisman B., Hirsch M. S., Allison A. C. Selective effects of anti-macrophage serum, silica and anti-lymphocyte serum on pathogenesis of herpes virus infection of young adult mice. J Immunol. 1970 May;104(5):1155–1159. [PubMed] [Google Scholar]

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