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. 1975 Aug;12(2):360–363. doi: 10.1128/iai.12.2.360-363.1975

Fowl Immunoglobulins: Quantitation in Birds Genetically Resistant and Susceptible to Marek's Disease

D A Higgins 1, B W Calnek 1
PMCID: PMC415292  PMID: 16558118

Abstract

The development of serum immunoglobulins was observed in chicks genetically resistant (N line) and susceptible (P line) to Marek's disease (MD), in conditions free from infection with MD. IgG was present at hatching at about 5.0 mg/ml and decreased to about 0.5 mg/ml by 12 to 15 days. Active production of IgG was apparent at about 20 days of age and reached levels of 2.0 to 3.0 mg/ml by 67 days. Low levels of IgM were present at hatching, and a gradual increase was seen to 1.0 to 2.0 mg/ml by 67 days. IgA was not detectable at hatching; it appeared in N-line birds at 5 days and in P-line birds at 13 days, and by 67 days was about 0.10 to 0.13 mg/ml. After 30 to 40 days, immunoglobulin levels were generally higher in N-line than in P-line birds. However, it was concluded that no primary immunoglobin deficiency existed sufficient to explain the susceptibility of the P-line birds to MD

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Avrameas S., Ternynck T. The cross-linking of proteins with glutaraldehyde and its use for the preparation of immunoadsorbents. Immunochemistry. 1969 Jan;6(1):53–66. doi: 10.1016/0019-2791(69)90178-5. [DOI] [PubMed] [Google Scholar]
  2. Calnek B. W., Hitchner S. B. Localization of viral antigen in chickens infected with Marek's disease herpesvirus. J Natl Cancer Inst. 1969 Oct;43(4):935–949. [PubMed] [Google Scholar]
  3. Calnek B. W. Influence of age at exposure on the pathogenesis of Marek's disease. J Natl Cancer Inst. 1973 Sep;51(3):929–939. doi: 10.1093/jnci/51.3.929. [DOI] [PubMed] [Google Scholar]
  4. Churchill A. E., Biggs P. M. Agent of Marek's disease in tissue culture. Nature. 1967 Jul 29;215(5100):528–530. doi: 10.1038/215528a0. [DOI] [PubMed] [Google Scholar]
  5. Cole R. K. Studies on genetic resistance to Marek's disease. Avian Dis. 1968 Feb;12(1):9–28. [PubMed] [Google Scholar]
  6. FAHEY J. L., MCKELVEY E. M. QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES. J Immunol. 1965 Jan;94:84–90. [PubMed] [Google Scholar]
  7. Hutt F. B., Cole R. K. Genetic Control of Lymphomatosis in the Fowl. Science. 1947 Oct 24;106(2756):379–384. doi: 10.1126/science.106.2756.379. [DOI] [PubMed] [Google Scholar]
  8. Jaffe W. P., Jaap R. G. A lack of effect of bursa size on disease resistance and antibody production. Poult Sci. 1966 Jan;45(1):157–159. doi: 10.3382/ps.0450157. [DOI] [PubMed] [Google Scholar]
  9. Kulkarni P. E. IgG-2 deficiency in gangrenous mastitis in cows. Acta Vet Scand. 1971;12(4):611–614. doi: 10.1186/BF03547731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Landreth K. S., Glick B., Good R. A. Differential effect of bursectomy on antibody production in a large and small bursa line of New Hampshire chickens. Proc Soc Exp Biol Med. 1973 Nov;144(2):501–505. doi: 10.3181/00379727-144-37622. [DOI] [PubMed] [Google Scholar]
  11. Leslie G. A., Clem L. W. Phylogen of immunoglobulin structure and function. 3. Immunoglobulins of the chicken. J Exp Med. 1969 Dec 1;130(6):1337–1352. doi: 10.1084/jem.130.6.1337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Leslie G. A., Martin L. N. Studies on the secretory immunologic system of fowl. 3. Serum and secretory IgA of the chicken. J Immunol. 1973 Jan;110(1):1–9. [PubMed] [Google Scholar]
  13. Leslie G. A., Martin L. N. Suppression of chicken immunoglobulin ontogeny by F(ab')2 fragments of anti-mu chain and by anti-L chain. Int Arch Allergy Appl Immunol. 1973;45(3):429–438. doi: 10.1159/000231060. [DOI] [PubMed] [Google Scholar]
  14. Nazerian K., Solomon J. J., Witter R. L., Burmester B. R. Studies on the etiology of Marek's disease. II. Finding of a herpesvirus in cell culture. Proc Soc Exp Biol Med. 1968 Jan;127(1):177–182. doi: 10.3181/00379727-127-32650. [DOI] [PubMed] [Google Scholar]
  15. Oxelius V. A. Chronic infections in a family with hereditary deficiency of IgG2 and IgG4. Clin Exp Immunol. 1974 May;17(1):19–27. [PMC free article] [PubMed] [Google Scholar]
  16. Sharma J. M., Purchase H. G. Replication of Marek's disease virus in cell cultures derived from genetically resistant chickens. Infect Immun. 1974 Jun;9(6):1092–1097. doi: 10.1128/iai.9.6.1092-1097.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Sharma J. M., Stone H. A. Genetic resistance to Marek's disease. Delineation of the response of genetically resistant chickens to Marek's disease virus infection. Avian Dis. 1972 Jul-Sep;16(4):894–906. [PubMed] [Google Scholar]
  18. Solomon J. J., Witter R. L., Nazerian K., Burmester B. R. Studies on the etiology of Marek's disease. I. Propagation of the agent in cell culture. Proc Soc Exp Biol Med. 1968 Jan;127(1):173–177. doi: 10.3181/00379727-127-32649. [DOI] [PubMed] [Google Scholar]
  19. Spencer J. L. Marek's disease herpesvirus: in vivo and in vitro infection of kidney cells of different genetic strains of chickens. Avian Dis. 1969 Nov;13(4):753–761. [PubMed] [Google Scholar]
  20. Trainin Z., Mairom R., Klopfer U., Meidan G. Levels of IgM and IgG in the sera of normal and leukaemic calves. J Comp Pathol. 1973 Jan;83(1):87–90. doi: 10.1016/0021-9975(73)90031-5. [DOI] [PubMed] [Google Scholar]
  21. Van Meter R., Good R. A., Cooper M. D. Ontogeny of circulating immunoglobulin in normal, bursectomized and irradiated chickens. J Immunol. 1969 Feb;102(2):370–374. [PubMed] [Google Scholar]

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