Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1975 Nov;12(5):939–942. doi: 10.1128/iai.12.5.939-942.1975

Induction of resistance with heat-killed compact-type strains of Staphylococcus aureus against challenge with the diffuse variant of the Smith strain of Staphylococcus aureus.

K Yoshida, Y Ichiman, T Otomo
PMCID: PMC415378  PMID: 1193730

Abstract

Active immunization of mice with high doses of heat-killed and autoclaved vaccine of unencapsulated strains of Staphylococcus aureus, which was grown in brain heart infusion media, protected against challenge with the Smith diffuse strain of Staphylococcus aureus. These organisms were capable of absorbing the protective antibody in rabbit hyperimmune sera prepared with the Smith diffuse strain. Also, mice treated with rabbit hyperimmune sera prepared with these strains (four out of six strains) protected against challenge with the Smith diffuse strain. Protective activities of these rabbit hyperimmune sera were assumed to be essentially identical to the protective antibody induced by the Smith diffuse strain.

Full text

PDF
939

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLAIR J. E., CARR M. The bacteriophage typing of staphylococci. J Infect Dis. 1953 Jul-Aug;93(1):1–13. doi: 10.1093/infdis/93.1.1. [DOI] [PubMed] [Google Scholar]
  2. Ekstedt R. D., Yoshida K. Immunity to staphylococcal infection in mice: effect of living versus killed vaccine, role of circulating antibody, and induction of protection-inducing antigen(s) in vitro. J Bacteriol. 1969 Nov;100(2):745–750. doi: 10.1128/jb.100.2.745-750.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FINKELSTEIN R. A., SULKIN S. E. Characteristics of coagulase positive and coagulase negative staphylococci in serum-soft agar. J Bacteriol. 1958 Mar;75(3):339–344. doi: 10.1128/jb.75.3.339-344.1958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FISHER M. W., DEVLIN H. B., ERLANDSON A. L. A NEW STAPHYLOCOCCAL ANTIGEN. ITS PREPARATION AND IMMUNIZING ACTIVITY AGAINST EXPERIMENTAL INFECTIONS. Nature. 1963 Sep 14;199:1074–1075. doi: 10.1038/1991074a0. [DOI] [PubMed] [Google Scholar]
  5. KOENIG M. G., MELLY M. A., ROGERS D. E. Factors relating to the virulence of Staphylococci. II. Observations on four mouse-pathogenic strains. J Exp Med. 1962 Nov 1;116:589–599. doi: 10.1084/jem.116.5.589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. MORSE S. I. Isolation and properties of a surface antigen of Staphylococcus aureus. J Exp Med. 1962 Feb 1;115:295–311. doi: 10.1084/jem.115.2.295. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Oeding P. Antigenic studies on Micrococcus strains. Acta Pathol Microbiol Scand. 1967;70(1):120–128. doi: 10.1111/j.1699-0463.1967.tb01275.x. [DOI] [PubMed] [Google Scholar]
  8. Smith M. R., Yoshida K., Naito Y. Use of the Clumping Factor Reaction for the Identification of Encapsulated Strains of Staphylococcus aureus from Human Sources. Infect Immun. 1971 May;3(5):707–708. doi: 10.1128/iai.3.5.707-708.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Yoshida K. Demonstration of Serologically Different Capsular Types Among Strains of Staphylococcus aureus by the Serum-Soft Agar Technique. Infect Immun. 1971 Apr;3(4):535–539. doi: 10.1128/iai.3.4.535-539.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Yoshida K., Ekstedt R. D. Antibody response to Staphylococcus aureus in rabbits: sequence of immunoglobulin synthesis and its correlation with passive protection in mice. J Bacteriol. 1968 Nov;96(5):1540–1545. doi: 10.1128/jb.96.5.1540-1545.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Yoshida K., Nakamura A., Otomo T., Iwami S. Detection of capsular antigen production in unencapsulated strains of Staphylococcus aureus. Infect Immun. 1974 Apr;9(4):620–623. doi: 10.1128/iai.9.4.620-623.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Yoshida K., Smith M. R., Naito Y. Biological and Immunological Properties of Encapsulated Strains of Staphylococcus aureus from Human Sources. Infect Immun. 1970 Nov;2(5):528–532. doi: 10.1128/iai.2.5.528-532.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Yoshida K., Takahashi M., Takeuchi Y. Pseudocompact-type growth and conversion of growth types of strains of Staphylococcus aureus in vitro and in vivo. J Bacteriol. 1969 Oct;100(1):162–166. doi: 10.1128/jb.100.1.162-166.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES