Abstract
Carbon sources utilized by virulent Treponema pallidum organisms extracted from infected rabbit tissue have been investigated. Utilization of 14C-labeled compounds by T. pallidum was monitored by degradation of these compounds to 14CO2. Experiments have consistently shown that of 22 carbon sources examined, [14C]glucose and [14C]pyruvate are selectively degraded to 14CO2 under the experimental conditions employed. When [1-14C]pyruvate, [2-14C]pyruvate, and [3-14C]pyruvate are tested, virulent T. pallidum preferentially degrade and release the carboxyl group as 14CO2. End product analyses indicate that CO2 and acetate are the major products of pyruvate degradation by T. pallidum.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baseman J. B., Hayes N. S. Protein synthesis by Treponema pallidum extracted from infected rabbit tissue. Infect Immun. 1974 Dec;10(6):1350–1355. doi: 10.1128/iai.10.6.1350-1355.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dobrogosz W. J. Altered end-product patterns and catabolite repression in Escherichia coli. J Bacteriol. 1966 Jun;91(6):2263–2269. doi: 10.1128/jb.91.6.2263-2269.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eagle H., Steinman H. G. The Nutritional Requirements of Treponemata: I. Arginine, Acetic Acid, Sulfur-containing Compounds, and Serum Albumin as Essential Growth-promoting Factors for the Reiter Treponeme. J Bacteriol. 1948 Aug;56(2):163–176. [PMC free article] [PubMed] [Google Scholar]
- Metzger M., Michalska E. A study on labeling Reiter treponemes and Treponema pallidum with 14C. Arch Immunol Ther Exp (Warsz) 1970;18(6):635–642. [PubMed] [Google Scholar]
- Metzger M., Smogór W. Study of the effect of pH and Eh values of the Nelson-Diesendruck medium on the survival of virulent Treponema pallidum. Arch Immunol Ther Exp (Warsz) 1966;14(4):445–453. [PubMed] [Google Scholar]
- WEBER M. M. Factors influencing the in vitro survival of Treponema pallidum. Am J Hyg. 1960 May;71:401–417. doi: 10.1093/oxfordjournals.aje.a120123. [DOI] [PubMed] [Google Scholar]