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. 1975 Dec;12(6):1258–1261. doi: 10.1128/iai.12.6.1258-1261.1975

Passive immunization in experimental Herpesvirus hominis infection of newborn mice.

F Luyet, D Samra, A Soneji, M I Marks
PMCID: PMC415429  PMID: 173653

Abstract

Infection of newborn mice with Herpesvirus hominis type 2(HVH-2) was used as an experimental model of disseminated HVH infection in newborn humans. Mice were challenged with 103 plaque-forming units of HVH-2 intranasally and were given 0.2 ml of rabbit serum intraperitoneally. Passive immunizations with rabbit anti-HVH-2 serum resulted in a significant decrease in mortality and prolongation of survival time. This effect correlated with the neutralizing antibody titer of the serum against HVH-2 and was more pronounced when immune serum was administered 1 h after infection as compared with 24 h. These results suggest that administration of high-titer anti-HVH-2 immunoglobulins shortly after delivery could afford significant protection to the newborn of a mother with genital HVH-2 infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker M. B., Larson C. L., Ushijima R. N., Anderson F. D. Resistance of female mice to vaginal infection induced by Herpesvirus hominis type 2: effects of immunization with Mycobacterium bovis, intravenous injection of specific Herpesvirus hominis type 2 antiserum, and a combination of these procedures. Infect Immun. 1974 Dec;10(6):1230–1234. doi: 10.1128/iai.10.6.1230-1234.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Becker W. B., Kipps A., McKenzie D. Disseminated herpes simplex virus infection. Its pathogenesis based on virological and pathological studies in 33 cases. Am J Dis Child. 1968 Jan;115(1):1–8. doi: 10.1001/archpedi.1968.02100010003001. [DOI] [PubMed] [Google Scholar]
  3. Ennis F. A. Host defense mechanisms against Herpes simplex virus. I. Control of infection in vitro by senstized spleen cells and antibody. Infect Immun. 1973 Jun;7(6):898–904. doi: 10.1128/iai.7.6.898-904.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gershon A. A., Steinberg S., Brunell P. A. Zoster immune globulin. A further assessment. N Engl J Med. 1974 Jan 31;290(5):243–245. doi: 10.1056/NEJM197401312900503. [DOI] [PubMed] [Google Scholar]
  5. Golden B., Bell W. E., McKee A. P. Disseminated herpes simplex with encephalitis in a neonate. Treatment with idoxuridine. JAMA. 1969 Aug 25;209(8):1219–1221. [PubMed] [Google Scholar]
  6. Gruia M., Muţiu A., Cristea A., Surdan C., Gologan R., Lupu R., Wecsler P. The action of human immunoglobulins in experimental herpes infection in the newborn rat. Rev Roum Virol. 1973;10(1):47–58. [PubMed] [Google Scholar]
  7. Hampar B., Notkins A. L., Mage M., Keehn M. A. Heterogeneity in the properties of 7 S and 19S rabbit-neutralizing antibodies to herpes simplex virus. J Immunol. 1968 Mar;100(3):586–593. [PubMed] [Google Scholar]
  8. Hanna L., Keshishyan H., Jawetz E., Coleman V. R. Diagnosis of Herpesvirus hominis infections in a general hospital laboratory. J Clin Microbiol. 1975 Mar;1(3):318–323. doi: 10.1128/jcm.1.3.318-323.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hanshaw J. B. Herpesvirus hominis infections in the fetus and the newborn. Am J Dis Child. 1973 Oct;126(4):546–555. doi: 10.1001/archpedi.1973.02110190442018. [DOI] [PubMed] [Google Scholar]
  10. Hirsch M. S., Murphy F. A. Effects of anti-lymphoid sera on viral infections. Lancet. 1968 Jul 6;2(7558):37–40. doi: 10.1016/s0140-6736(68)92904-8. [DOI] [PubMed] [Google Scholar]
  11. Kern E. R., Overall J. C., Jr, Glasgow L. A. Herpesvirus hominis infection in newborn mice. I. An experimental model and therapy with iododeoxyuridine. J Infect Dis. 1973 Sep;128(3):290–299. doi: 10.1093/infdis/128.3.290. [DOI] [PubMed] [Google Scholar]
  12. Light I. J., Linnemann C. C., Jr Neonatal herpes simplex infection following delivery by cesarean section. Obstet Gynecol. 1974 Oct;44(4):496–499. [PubMed] [Google Scholar]
  13. Lodmell D. L., Niwa A., Hayashi K., Notkins A. L. Prevention of cell-to-cell spread of herpes simplex virus by leukocytes. J Exp Med. 1973 Mar 1;137(3):706–720. doi: 10.1084/jem.137.3.706. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Lodmell D. L., Notkins A. L. Cellular immunity to herpes simplex virus mediated by interferon. J Exp Med. 1974 Sep 1;140(3):764–778. doi: 10.1084/jem.140.3.764. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Marks M. I. Evaluation of four antiviral agents in the treatment of herpes simplex encephalitis in a rat model. J Infect Dis. 1975 Jan;131(1):11–16. doi: 10.1093/infdis/131.1.11. [DOI] [PubMed] [Google Scholar]
  16. Marks M. I. Method for the preparation of a herpesvirus hominis fluorescent conjugate for direct immunofluorescence. Arch Gesamte Virusforsch. 1970;32(4):373–378. doi: 10.1007/BF01250065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Monif G. R., Brunell P. A., Hsiung G. D. Visceral involvement by herpes simplex virus in eczema herpeticum. Am J Dis Child. 1968 Sep;116(3):324–327. doi: 10.1001/archpedi.1968.02100020326018. [DOI] [PubMed] [Google Scholar]
  18. Montgomerie J. Z., Becroft D. M., Croxson M. C., Doak P. B., North J. D. Herpes-simplex-virus infection after renal transplantation. Lancet. 1969 Oct 25;2(7626):867–871. doi: 10.1016/s0140-6736(69)92327-7. [DOI] [PubMed] [Google Scholar]
  19. Muller S. A., Herrmann E. C., Jr, Winkelmann R. K. Herpes simplex infections in hematologic malignancies. Am J Med. 1972 Jan;52(1):102–114. doi: 10.1016/0002-9343(72)90012-5. [DOI] [PubMed] [Google Scholar]
  20. Nahmias A. J., Alford C. A., Korones S. B. Infection of the newborn with herpesvirus hominis. Adv Pediatr. 1970;17:185–226. [PubMed] [Google Scholar]
  21. Nahmias A. J. Disseminated herpes-simplex-virus infections. N Engl J Med. 1970 Mar 19;282(12):684–685. doi: 10.1056/NEJM197003192821213. [DOI] [PubMed] [Google Scholar]
  22. Nahmias A. J., Josey W. E., Naib Z. M., Freeman M. G., Fernandez R. J., Wheeler J. H. Perinatal risk associated with maternal genital herpes simplex virus infection. Am J Obstet Gynecol. 1971 Jul 15;110(6):825–837. doi: 10.1016/0002-9378(71)90580-1. [DOI] [PubMed] [Google Scholar]
  23. Nahmias A. J., Roizman B. Infection with herpes-simplex viruses 1 and 2. 1. N Engl J Med. 1973 Sep 27;289(13):667–674. doi: 10.1056/NEJM197309272891305. [DOI] [PubMed] [Google Scholar]
  24. Rasmussen L. E., Jordan G. W., Stevens D. A., Merigan T. C. Lymphocyte interferon production and transformation after Herpes simplex infections in humans. J Immunol. 1974 Feb;112(2):728–736. [PubMed] [Google Scholar]
  25. Rosen P., Hajdu S. I. Visceral herpesvirus infections in patients with cancer. Am J Clin Pathol. 1971 Oct;56(4):459–465. doi: 10.1093/ajcp/56.4.459. [DOI] [PubMed] [Google Scholar]
  26. Rosenberg G. L., Notkins A. L. Induction of cellular immunity to herpes simplex virus: relationship to the humoral immune response. J Immunol. 1974 Mar;112(3):1019–1025. [PubMed] [Google Scholar]
  27. Russell A. S. Cell-mediated immunity to herpes simplex virus in man. J Infect Dis. 1974 Feb;129(2):142–146. doi: 10.1093/infdis/129.2.142. [DOI] [PubMed] [Google Scholar]
  28. Russell A. S., Percy J. S., Kovithavongs T. Cell-mediated immunity to Herpes simplex in humans: lymphocyte cytotoxicity measured by 51-Cr release from infected cells. Infect Immun. 1975 Feb;11(2):355–359. doi: 10.1128/iai.11.2.355-359.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Scriba M. Stimulation of peripheral blood lymphocytes by herpes simplex virus in vitro. Infect Immun. 1974 Sep;10(3):430–436. doi: 10.1128/iai.10.3.430-436.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Shore S. L., Nahmias A. J., Starr S. E., Wood P. A., McFarlin D. E. Detection of cell-dependent cytotoxic antibody to cells infected with herpes simplex virus. Nature. 1974 Sep 27;251(5473):350–352. doi: 10.1038/251350a0. [DOI] [PubMed] [Google Scholar]
  31. Tokumaru T. The protective effect of different immunoglobulins against herpetic encephalitis and skin infection in guinea pigs. Arch Gesamte Virusforsch. 1967;22(3):332–348. doi: 10.1007/BF01242954. [DOI] [PubMed] [Google Scholar]
  32. WHEELER C. E., Jr, HUFFINES W. D. PRIMARY DISSEMINATED HERPES SIMPLEX OF THE NEWBORN. JAMA. 1965 Feb 8;191:455–460. doi: 10.1001/jama.1965.03080060029005. [DOI] [PubMed] [Google Scholar]
  33. WHITE J. G. Fulminating infection with herpes-simplex virus in premature and newborn infants. N Engl J Med. 1963 Aug 29;269:455–460. doi: 10.1056/NEJM196308292690906. [DOI] [PubMed] [Google Scholar]
  34. ZUELZER W. W., STULBERG C. S. Herpes simplex virus as the cause of fulminating visceral disease and hepatitis in infancy; report of eight cases and isolation of the virus in one case. AMA Am J Dis Child. 1952 Apr;83(4):421–439. doi: 10.1001/archpedi.1952.02040080017001. [DOI] [PubMed] [Google Scholar]
  35. Zisman B., Hirsch M. S., Allison A. C. Selective effects of anti-macrophage serum, silica and anti-lymphocyte serum on pathogenesis of herpes virus infection of young adult mice. J Immunol. 1970 May;104(5):1155–1159. [PubMed] [Google Scholar]

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