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. 1975 Dec;12(6):1271–1275. doi: 10.1128/iai.12.6.1271-1275.1975

Induction of heat-labile enterotoxin synthesis in enterotoxigenic Escherichia coli mitomycin C.

R E Isaacson, H W Moon
PMCID: PMC415431  PMID: 1107223

Abstract

Introduction of heat-labile toxin (LT) synthesis in enterotocigenic strains of Escherichia coli by mitomycin C (MTC) was demonstrated. Six enteropathogenic strains which produce LT were inducible, exhibiting an 896-fold increase in LT when compared to ininduced cultures. On the other hand, four nonenteropathogens and three other pathogens which produce only the heat-stable toxin were not induced to produce LT. Gel filtration chromatography, antibody neutration, and heat lability studies suggest that the toxin synthesized in the presence of MTC is the same as the toxin synthesized in the absence of MTC.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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