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. 1975 Dec;12(6):1349–1354. doi: 10.1128/iai.12.6.1349-1354.1975

Mycoplasma-mediated hyporeactivity to various interferon inducers.

B C Cole, J C Overall Jr, P S Lombardi, L A Glasgow
PMCID: PMC415442  PMID: 1205616

Abstract

Three strains of Mycoplasma arthritidis were shown to induce marked hyporeactivity in mice to interferon induction by both Newcastle disease virus and poly(I:C). In contrast, the interferon response of mice to tilorone was only partially suppressed by pretreatment of the animals with mycoplasms. Hyporeactivity to Newcastle disease virus was maximal 1 and 3 days after mycoplasms treatment, but the interferon response was maximal 1 day after injection of the mycoplasmas and was no longer apparent by 5 days. No relationship was found between the ability of the mycoplasms themselves to induce interferon and the degree of hyporeactivity produced. These results suggest that mycoplasmas may alter virus-host relationships in vivo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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