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Infection and Immunity logoLink to Infection and Immunity
. 1976 Oct;14(4):858–871. doi: 10.1128/iai.14.4.858-871.1976

T cells and protective immunity to Plasmodium berghei in rats.

K N Brown, W Jarra, L A Hills
PMCID: PMC415464  PMID: 791865

Abstract

Experiments were carried out in which unfractionated spleen cells, and T lymphocyte subpopulations characterized by certain experimental criteria, were isolated at various times from rats infected with Plasmodium berghei. By adoptive transfer it was shown that unfractionated spleen cells, and T cells alone, could transfer protection to syngenic recipients as early as 11 days after infection of the cell donors. The protection conferred by T cells increased with the duration of the infection in the donors, at least up to 100 days. The additional presence of B cells in transferred lymphocyte populations enhanced their protective capacity over that shown by T cells alone. The role of T cells in protective immunity to malaria is discussed.

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Selected References

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