Abstract
Experimental endogenous endophthalmitis was produced in infant rats by either intranasal or intraperitoneal inoculation with Haemophilus influenzae type b and 5 days of age. The ocular disease occurred in about 50% of bacteremic animals who survived to age 12 days and probably represents metastatic bacterial infection secondary to hematogenous seeding. The lesion was a highly destructive suppurative endophthalmitis that ultimately progressed to panophthalmitis and was followed by organization of the exudate and phthisis bulbi.
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- ALMEDA E. M. Metastatic pneumococcic endophthalmitis secondary to pneumococcic meningitis. Am J Ophthalmol. 1960 Feb;49:353–355. doi: 10.1016/0002-9394(60)91530-0. [DOI] [PubMed] [Google Scholar]
- Edwards J. E., Jr, Montgomerie J. Z., Foos R. Y., Shaw V. K., Guze L. B. Experimental hematogenous endophthalmitis caused by Candida albicans. J Infect Dis. 1975 Jun;131(6):649–657. doi: 10.1093/infdis/131.6.649. [DOI] [PubMed] [Google Scholar]
- FRENKEL J. K. Ocular lesions in hamsters; with chronic Toxoplasma and Besnoitia infection. Am J Ophthalmol. 1955 Feb;39(2 Pt 2):203–225. [PubMed] [Google Scholar]
- Frantz J. F., Lemp M. A., Font R. L., Stone R., Eisner E. Acute endogenous panophthalmitis caused by Clostridium perfringens. Am J Ophthalmol. 1974 Aug;78(2):295–303. doi: 10.1016/0002-9394(74)90092-0. [DOI] [PubMed] [Google Scholar]
- HEDGES T. R., Jr, MCALLISTER R., CORIELL L. L., MOORE W. Metastatic endophthalmitis as a complication of meningococcic meningitis. AMA Arch Ophthalmol. 1956 Apr;55(4):503–505. doi: 10.1001/archopht.1956.00930030507006. [DOI] [PubMed] [Google Scholar]
- MAYLATH F. R., LEOPOLD I. H. Study of experimental intraocular infection. I. The recoverability of organisms inoculated into ocular tissues and fluids. II. The influence of antibiotics and cortisone, alone and combined, on intraocular growth of these organisms. Am J Ophthalmol. 1955 Jul;40(1):86–101. [PubMed] [Google Scholar]
- Macoul K. L. Pneumococcal septicemia presenting as a hypopyon. Arch Ophthalmol. 1969 Jan;81(1):144–145. doi: 10.1001/archopht.1969.00990010146019. [DOI] [PubMed] [Google Scholar]
- Michaels R. H., Poziviak C. S. Countercurrent immunoelectrophoresis for the diagnosis of pneumococcal pneumonia in children. J Pediatr. 1976 Jan;88(1):72–74. doi: 10.1016/s0022-3476(76)80730-5. [DOI] [PubMed] [Google Scholar]
- Michaels R. H., Stonebraker F. E., Robbins J. B. Use of antiserum agar for detection of Haemophilus influenzae type b in the pharynx. Pediatr Res. 1975 May;9(5):513–516. doi: 10.1203/00006450-197505000-00010. [DOI] [PubMed] [Google Scholar]
- Moxon E. R., Smith A. L., Averill D. R., Smith D. H. Haemophilus influenzae meningitis in infant rats after intranasal inoculation. J Infect Dis. 1974 Feb;129(2):154–162. doi: 10.1093/infdis/129.2.154. [DOI] [PubMed] [Google Scholar]
- Pribnow J. F., Hall J. M., Bradley D., Vedros N. A. Cellular Response of the Rabbit Eye to Primary Intravitreal Injection of Neisseria meningitidis. Infect Immun. 1971 Jun;3(6):739–746. doi: 10.1128/iai.3.6.739-746.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pribnow J. F., Hall J. M., Stewart R. H., Vedros N. A. The ocular inflammation produced following intravitreal injection of a stable L-phase variant of Neisseria meningitidis. Can J Ophthalmol. 1973 Apr;8(2):361–365. [PubMed] [Google Scholar]
- Schneerson R., Robbins J. B. Age-related susceptibility to Haemophilus influenzae type b disease in rabbits. Infect Immun. 1971 Oct;4(4):397–401. doi: 10.1128/iai.4.4.397-401.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Simmons R. E., O'Rourke J. Intra-arterial infusion therapy of pseudomonas and staphylococcal endophthalmitis in dogs. Am J Ophthalmol. 1968 Aug;66(2):295–299. doi: 10.1016/0002-9394(68)92078-3. [DOI] [PubMed] [Google Scholar]
- Smith A. L., Smith D. H., Averill D. R., Jr, Marino J., Moxon E. R. Production of Haemophilus influenzae b meningitis in infant rats by intraperitoneal inoculation. Infect Immun. 1973 Aug;8(2):278–290. doi: 10.1128/iai.8.2.278-290.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WITMER R. H. Experimental leptospiral uveitis in rabbits. AMA Arch Ophthalmol. 1954 Apr;53(4):547–559. doi: 10.1001/archopht.1955.00930010555015. [DOI] [PubMed] [Google Scholar]