Abstract
Trophozoites of Toxoplasma gondii from mouse peritoneal exudate are capable of shedding antibodies with which they have been previously coated. The antibodies are first moved towards the anterior pole of the parasite, at which they form a "cap". From the pole they are shed into the environment in the form of antigen-antibody complexes. An internalization of the accumulated material has never been encountered. Most probably, the observed phenomenon reflects a mechanism by which the parasite evades the host's immune response.
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Selected References
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- Creighton W. D., Lambert P. H., Miescher P. A. Detection of antibodies and soluble antigen-antibody complexes by precipitation with polyethylene glycol. J Immunol. 1973 Oct;111(4):1219–1227. [PubMed] [Google Scholar]
- Doyle J. J., Behin R., Mauel J., Rowe D. S. Antibody-induced movement of membrane components of Leishmania enriettii. J Exp Med. 1974 May 1;139(5):1061–1069. doi: 10.1084/jem.139.5.1061. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Doyle J. J., Behin R., Mauel J., Rowe D. S. Antibody-induced movement of protozoan surface membrane antigens. Ann N Y Acad Sci. 1975 Jun 30;254:315–325. doi: 10.1111/j.1749-6632.1975.tb29181.x. [DOI] [PubMed] [Google Scholar]
- Dzbeński T. H., Zielińska E. Antibody-induced formation of caps in Toxoplasma gondii. Experientia. 1976 Apr 15;32(4):454–456. doi: 10.1007/BF01920792. [DOI] [PubMed] [Google Scholar]
- Ferguson D. J., Hutchison W. M., Siim J. C. The ultrastructural development of the macrogamete and formation of the oocyst wall of Toxoplasma gondii. Acta Pathol Microbiol Scand B. 1975 Oct;83(5):491–505. doi: 10.1111/j.1699-0463.1975.tb00130.x. [DOI] [PubMed] [Google Scholar]
- Graham R. C., Jr, Karnovsky M. J. The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. J Histochem Cytochem. 1966 Apr;14(4):291–302. doi: 10.1177/14.4.291. [DOI] [PubMed] [Google Scholar]
- Guclu A., Tai J., Ghose T. Endocytosis of chlorambucil-bound anti-tumor globulin following "capping" in EL4 lymphoma cells. Immunol Commun. 1975;4(3):229–242. doi: 10.3109/08820137409055776. [DOI] [PubMed] [Google Scholar]
- Jones T. C., Hirsch J. G. The interaction between Toxoplasma gondii and mammalian cells. II. The absence of lysosomal fusion with phagocytic vacuoles containing living parasites. J Exp Med. 1972 Nov 1;136(5):1173–1194. doi: 10.1084/jem.136.5.1173. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McConahey P. J., Dixon F. J. A method of trace iodination of proteins for immunologic studies. Int Arch Allergy Appl Immunol. 1966;29(2):185–189. doi: 10.1159/000229699. [DOI] [PubMed] [Google Scholar]
- Nakane P. K., Kawaoi A. Peroxidase-labeled antibody. A new method of conjugation. J Histochem Cytochem. 1974 Dec;22(12):1084–1091. doi: 10.1177/22.12.1084. [DOI] [PubMed] [Google Scholar]
- Nicolson G. L. Temperature-dependent mobility of concanavalin A sites on tumour cell surfaces. Nat New Biol. 1973 Jun 13;243(128):218–220. doi: 10.1038/newbio243218a0. [DOI] [PubMed] [Google Scholar]
- Shulman N. R., Barker L. F. Virus-like antigen, antibody, and antigen-antibody complexes in hepatitis measured by complement fixation. Science. 1969 Jul 18;165(3890):304–306. doi: 10.1126/science.165.3890.304. [DOI] [PubMed] [Google Scholar]
- Silva P. P., Martínez-Palomo A., Gonzalez-Robles A. Membrane structure and surface coat of Entamoeba histolytica. Topochemistry and dynamics of the cell surface: cap formation and microexudate. J Cell Biol. 1975 Mar;64(3):538–550. doi: 10.1083/jcb.64.3.538. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sundqvist K. G. Redistribution of surface antigens--a general property of animal cells? Nat New Biol. 1972 Oct 4;239(92):147–149. doi: 10.1038/newbio239147a0. [DOI] [PubMed] [Google Scholar]
- Unanue E. R., Perkins W. D., Karnovsky M. J. Endocytosis by lymphocytes of complexes of anti-Ig with membrane-bound Ig. J Immunol. 1972 Feb;108(2):569–572. [PubMed] [Google Scholar]