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. 1976 Dec;14(6):1284–1289. doi: 10.1128/iai.14.6.1284-1289.1976

Effect of warfarin on the induction and course of experimental endocarditis.

J Thompson, F Eulderink, H Lemkes, R van Furth
PMCID: PMC415528  PMID: 1002298

Abstract

The effect of warfarin treatment on an experimental endocarditis was studied in rabbits. Warfarin had no effect on the induction of a Streptococcus sanguis infection in catheter-induced endocardial vegetations, and the course of this infection was also unaltered. However, warfarin treatment resulted in rapidly progressive bacteremia, probably due to impaired circulation in clearing organs such as the lungs, liver, and spleen. Warfarin also reduced the survival time of the infected rabbits, in which pulmonary edema and extensive lung hemorrhages may have been a contributory factor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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