Abstract
Strains of gonococcus were shown to be immunologically heterologous. Serum bactericidal activity generally correlated with induced immunity to gonococcal challenge as detected by the guinea pig subcutaneous chamber model. Sera devoid of bactericidal activity reflected the lack of cross-protection in subcutaneous chambers. Factors affecting the bactericidal assay described in this report include (i) source of complement, (ii) concentration of test antigen and complement activity, and (iii) presence of calcium and magnesium ions and bovine serum albumin in diluent. Poor correlation was observed between agglutinating activity of the immune sera and protection.
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Selected References
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- Arko R. J. An immunologic model in laboratory animals for the study of Neisseria gonorrhoeae. J Infect Dis. 1974 Apr;129(4):451–455. doi: 10.1093/infdis/129.4.451. [DOI] [PubMed] [Google Scholar]
- Arko R. J., Duncan W. P., Brown W. J., Peacock W. L., Tomizawa T. Immunity in infection with Neisseria gonorrhoeae: duration and serological response in the chimpanzee. J Infect Dis. 1976 Apr;133(4):441–447. [PubMed] [Google Scholar]
- Arko R. J. Neisseria gonorrhoeae: experimental infection of laboratory animals. Science. 1972 Sep 29;177(4055):1200–1201. doi: 10.1126/science.177.4055.1200. [DOI] [PubMed] [Google Scholar]
- Arko R. J., Wong K. H., Bullard J. C., Logan L. C. Immunological and serological diversity of Neisseria gonorrhoeae: immunotyping of gonococci by cross-protein in guinea pig subcutaneous chambers. Infect Immun. 1976 Dec;14(6):1293–1296. doi: 10.1128/iai.14.6.1293-1296.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Glynn A. A., Ward M. E. Nature and Heterogeneity of the Antigens of Neisseria gonorrhoeae Involved in the Serum Bactericidal Reaction. Infect Immun. 1970 Aug;2(2):162–168. doi: 10.1128/iai.2.2.162-168.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Reilly R. J., Welch B. G., Kellogg D. S., Jr An indirect fluorescent-antibody technique for study of uncomplicated gonorrhea. II. Selection and characterization of the strain of Neisseria gonorrhoeae used as antigen. J Infect Dis. 1973 Jan;127(1):77–83. doi: 10.1093/infdis/127.1.77. [DOI] [PubMed] [Google Scholar]
- Thayer J. D., Martin J. E., Jr Improved medium selective for cultivation of N. gonorrhoeae and N. meningitidis. Public Health Rep. 1966 Jun;81(6):559–562. [PMC free article] [PubMed] [Google Scholar]
- Tramont E. C., Sadoff J. C., Artenstein M. S. Cross-reactivity of Neisseria gonorrhoeae and Neisseria meningitidis and the nature of antigens involved in the bactericidal reaction. J Infect Dis. 1974 Sep;130(3):240–247. doi: 10.1093/infdis/130.3.240. [DOI] [PubMed] [Google Scholar]
- Turner W. H., Novotny P. The inability of Neisseria gonorrhoeae pili antibodies to confer immunity in subcutaneous guinea-pig chambers. J Gen Microbiol. 1976 Jan;92(1):224–228. doi: 10.1099/00221287-92-1-224. [DOI] [PubMed] [Google Scholar]