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. Author manuscript; available in PMC: 2014 Sep 9.
Published in final edited form as: Hepatology. 2011 Jul;54(1):133–144. doi: 10.1002/hep.24341

Fig. 2.

Fig. 2

Long-term HFD diet–induced steatohepatitis is associated with increased IL-1β production and NALP3 inflammasome activation in the liver. C57Bl/6 mice were fed an HFD or a control diet for 4 weeks or 9 months. The liver mRNA fold changes for IL-1β and the NALP3 inflammasome complex (including NALP3, ASC, caspase-1, and pannexin-1) were determined after (A) 4 weeks or (B) 9 months of HFD feeding. The functional activity of the inflammasome was evaluated by measurements of (C) the caspase-1 activity and (D) the mature IL-1β protein levels in the liver. (E) Liver triglycerides were measured (six mice per group). *P < 0.05 versus the corresponding control group.