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. 1970 Jan;1(1):74–77. doi: 10.1128/iai.1.1.74-77.1970

Inhibition of the Synthesis of Wax D Peptidoglycolipid of Mycobacterium tuberculosis by d-Cycloserine

Hugo L David 1, Dexter S Goldman 1, Kuni Takayama 1
PMCID: PMC415857  PMID: 16557697

Abstract

The antibiotic d-cycloserine inhibits the synthesis of the wax D peptidoglycolipid in cells of the H37Ra strain of Mycobacterium tuberculosis. This inhibition occurs at a lower concentration of the drug than that required for the inhibition of growth. The inhibition is completely reversed by d-alanine. An arabino-galactan-galactosamine-(diaminopimelic acid)-mycolate accumulates in H37Ra cells exposed to the antibiotic. The chemical and functional group analyses of this lipid suggests it to be a possible precursor to the synthesis of wax D.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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