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. 1970 Jan;1(1):120–127. doi: 10.1128/iai.1.1.120-127.1970

Resistance Factor-Mediated Spectinomycin Resistance

David H Smith 1, J A Janjigian 1, Naomi Prescott 1, Porter W Anderson 1
PMCID: PMC415863  PMID: 16557684

Abstract

Of 100 natural isolates of drug-resistant enteric bacteria, 51 were resistant to spectinomycin (Spc) and 46 contained transferable R factors mediating Spc resistance. All SpcR R factors mediated streptomycin and bluensomycin resistance and were fi+ type. Extracts of R-SpcR strains adenylated Spc, dihydrospectinomycin, actinamine, streptomycin, and bluensomycin in vitro in the presence of adenosine triphosphate and Mg++. Results of genetic and biochemical studies support the hypothesis that these reactions are mediated by a single enzyme.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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