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Infection and Immunity logoLink to Infection and Immunity
. 1970 May;1(5):440–445. doi: 10.1128/iai.1.5.440-445.1970

Subcellular Localization of Salmonella enteritidis Endotoxin in Liver and Spleen of Mice and Rats

James T Willerson 1, Robert L Trelstad 1, Theodore Pincus 1, Stuart B Levy 1, Sheldon M Wolff 1
PMCID: PMC415921  PMID: 16557755

Abstract

Salmonella enteritidis14C-endotoxin was recovered predominantly from the nuclear and mitochondrial subcellular fractions of livers and spleens of mice and rats, 3.5 hr and 3 days after intravenous administration. Of the recovered radioactivity, 10 to 20% was present in the liver mitochondrial fraction as high-molecular-weight, biologically active material, suggesting the presence of intact endotoxin. Autoradiographic studies demonstrated nuclear and cytoplasmic labeling in the liver and at least nuclear label in spleen cells. The resistance of rats, as compared to mice, to the induction of amyloidosis does not appear to be based on a difference in subcellular localization of endotoxin within the reticuloendothelial system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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