Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1970 May;1(5):485–490. doi: 10.1128/iai.1.5.485-490.1970

Effect of Bactericidal Substance from Staphylococcus aureus on Group A Streptococci I. Biochemical Alterations

Adnan S Dajani 1, Ernest D Gray 1, Lewis W Wannamaker 1
PMCID: PMC415929  PMID: 16557763

Abstract

A bactericidal substance isolated from phage type 71 staphylococci has been studied relative to its mechanism of action on streptococcal cells. The substance exerts its effect best at 37 C. No cell lysis occurs as evidenced by lack of alteration in optical density of susceptible cell suspensions. The bactericidal substance results in immediate cessation of protein and deoxyribonucleic acid synthesis as well as degradation of newly and previously formed ribonucleic acid (RNA). The action on RNA seems to be independent of protein synthesis.

Full text

PDF
485

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bradley D. E. Ultrastructure of bacteriophage and bacteriocins. Bacteriol Rev. 1967 Dec;31(4):230–314. doi: 10.1128/br.31.4.230-314.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Dajani A. S., Gray E. D., Wannamaker L. W. Bactericidal substance from Staphylococcus aureus. Biological properties. J Exp Med. 1970 May 1;131(5):1004–1015. doi: 10.1084/jem.131.5.1004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dajani A. S., Wannamaker L. W. Demonstration of a bactericidal substance against beta-hemolytic streptococci in supernatant fluids of staphylococcal cultures. J Bacteriol. 1969 Mar;97(3):985–991. doi: 10.1128/jb.97.3.985-991.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Elgat M., Ben-Gurion R. Mode of action of pesticin. J Bacteriol. 1969 May;98(2):359–367. doi: 10.1128/jb.98.2.359-367.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. IVANOVICS G., ALFOLDI L., NAGY E. Mode of action of megacin. J Gen Microbiol. 1959 Aug;21:51–60. doi: 10.1099/00221287-21-1-51. [DOI] [PubMed] [Google Scholar]
  6. IVANOVICS G., ALFOLDI L. Observations on lysogenesis in B. megaterium and on megacine, the antibacterial principle of this bacillus species. Acta Microbiol Acad Sci Hung. 1955;2(3):275–292. [PubMed] [Google Scholar]
  7. Ivanovics G. BACTERIOCINS AND BACTERIOCIN-LIKE SUBSTANCES. Bacteriol Rev. 1962 Jun;26(2 Pt 1):108–118. [PMC free article] [PubMed] [Google Scholar]
  8. REEVES P. THE BACTERIOCINS. Bacteriol Rev. 1965 Mar;29:24–45. doi: 10.1128/br.29.1.24-45.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES