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. 1970 Jul;2(1):96–100. doi: 10.1128/iai.2.1.96-100.1970

Responses of the Peyer's Patches in Germ-Free Mice to Antigenic Stimulation

Morris Pollard 1, Nehama Sharon 1
PMCID: PMC415970  PMID: 16557807

Abstract

Lymph nodes, spleens, and Peyer's patches of germ-free mice are relatively inactive. The tissues are small and contain rare, small, indistinct, germinal zones. When exposed to antigenic stimuli (Salmonella paratyphi A and lymphocytic choriomeningitis virus), the tissues become larger and germinal zones appear coincident with antibodies in the blood. The Peyer's patches were activated if antigen was absorbed from the intestinal lumen into the circulation but not if the antigen was administered parenterally. There was no demonstrable immunological response by the germ-free mouse to Streptococcus faecalis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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