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. 1970 Aug;2(2):150–155. doi: 10.1128/iai.2.2.150-155.1970

Distribution of Echovirus Antibody in Serum, Nasopharynx, Rectum, and Spinal Fluid After Natural Infection with Echovirus Type 6

Pearay L Ogra 1
PMCID: PMC415982  PMID: 16557813

Abstract

By employing the techniques of radioimmunodiffusion and autoradiography and by using 32P-labeled echovirus 6 as the antigen, the distribution of echovirus 6 antibody in serum, nasopharynx, rectum, and spinal fluid was studied in a group of children with naturally acquired echovirus type 6 infection, with or without meningeal involvement. The response in serum was characterized by sequential appearance of γM, γG, and rarely of γA antibody. The secretory response in the nasopharynx and rectum was limited to secretory γA immunoglobulin. The response in spinal fluid was limited to γG immunoglobulin. γG echovirus antibody appeared in the spinal fluid with or without demonstrable replication of virus in the spinal fluid. It is suggested that, after short-term acute infection with enteroviruses, the appearance of γG antibody in spinal fluid may largely be a reflection of increased transport of serum antibody, particularly of γG immunoglobulin class.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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