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. 1970 Sep;2(3):279–285. doi: 10.1128/iai.2.3.279-285.1970

Role of Cell Wall Structure of Salmonella in the Interaction with Phagocytes

D Friedberg 1, M Shilo 1
PMCID: PMC416002  PMID: 16557832

Abstract

Wild-type and cell wall mutants of Salmonella were examined for sensitivity to ingestion and intracellular killing in vitro by mouse peritoneal macrophages and guinea pig polymorphonuclear leukocytes. A complete polysaccharide core of the cell wall is important for resisting ingestion and intracellular killing, and the presence of the O-specific side chains contributes further resistance. Uridine diphosphate-gal-4-epimeraseless mutants grown on galactose-supplemented medium, rendering them smooth phenotypes, showed resistance to ingestion and intracellular killing similar to the wild type.

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Selected References

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