Abstract
The effect of several steroid hormones on the susceptibility of mice to infection with MM virus was studied. Estrone, cortisone, and hydrocortisone increased mortality, whereas progesterone, prednisolone, and testosterone had no effect. The viral infection-enhancing (VIE) activity of estrone was maximal when the hormone was given 24 to 72 hr prior to viral inoculation. Less VIE activity was seen when the estrone was administered at the same time as the virus, and hormone treatment 24 hr after inoculation had no significant effect on mortality. Virus was found in the blood 24 hr before it appeared in the brain, regardless of estrone treatment. However, viremia was demonstrated in estrone-treated mice 48 hr before it occurred in control animals. There was no significant difference in the respective titers reached in the sera or the brains of the two groups.
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Selected References
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- GLEISER C. A., GOCHENOUR W. S., Jr, BERGE T. O., TIGERTT W. D. Studies on the virus of Venezuelan equine encephalomyelitis. I. Modification by cortisone of the response of the central nervous system of Macaca mulatta. J Immunol. 1961 Nov;87:504–508. [PubMed] [Google Scholar]
- Giron D. J. Role of interferon in the propagation of MM virus in L cells. Appl Microbiol. 1969 Oct;18(4):584–588. doi: 10.1128/am.18.4.584-588.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KALTER S. S., STUART D. C., Jr, TEPPERMAN J. Alterations in rate of influenza virus proliferation produced by growth hormone and testosterone. Proc Soc Exp Biol Med. 1950 Jul;74(3):605–607. doi: 10.3181/00379727-74-17990. [DOI] [PubMed] [Google Scholar]
- KILBOURNE E. D., HORSFALL F. L., Jr Lethal infection with coxsackie virus of adult mice given cortisone. Proc Soc Exp Biol Med. 1951 May;77(1):135–138. doi: 10.3181/00379727-77-18702. [DOI] [PubMed] [Google Scholar]
- Postic B., DeAngelis C., Breinig M. K., Ho M. Effects of cortisol and adrenalectomy on induction of interferon by endotoxin. Proc Soc Exp Biol Med. 1967 May;125(1):89–92. doi: 10.3181/00379727-125-32021. [DOI] [PubMed] [Google Scholar]
- REINICKE V. THE INFLUENCE OF HYDROCORTISONE ON PRODUCTION OF INFLUENZAVIRUS AND INTERFERON IN OVO. Acta Pathol Microbiol Scand. 1964;60:528–539. doi: 10.1111/apm.1964.60.4.528. [DOI] [PubMed] [Google Scholar]
- Reinicke V. The influence of steroid hormones and growth hormones on the production of influenza virus and interferon in tissue culture. 2. The influence of metandienonum, d-aldosterone, testosterone, oestradiol and growth hormones. Acta Pathol Microbiol Scand. 1965;64(4):553–560. doi: 10.1111/apm.1965.64.4.553. [DOI] [PubMed] [Google Scholar]
- Rytel M. W., Kilbourne E. D. The influence of cortisone on experimental viral infection. 8. Suppression by cortisone of interferon formation in mice injected with Newcastle disease virus. J Exp Med. 1966 May 1;123(5):767–775. doi: 10.1084/jem.123.5.767. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SHWARTZMAN G. Enhancing effect of cortisone upon poliomyelitis infection (Strain MEF1) in hamsters and mice. Proc Soc Exp Biol Med. 1950 Dec;75(3):835–838. doi: 10.3181/00379727-75-18362. [DOI] [PubMed] [Google Scholar]